morphine is a Medicine belongs to Opoid analgesic group whose information about Brand can be referenced from   Book :

  ►   Brandname : NA

  ►  Strength :

A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : NA


Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Pain Oral 5 20 mg Tablet Every 4 hours.
2 Pain rectal 10 30 mg Suppository Every 4 hours.
3 Pain s.c/ i.m 10 mg Injection Every 4 hours.
4 Premedication s.c/ i.m 10 mg Injection 60 to 90 minutes before surgery.
5 Pain IV 15 mg Injection
6 Myocardial infarction IV 5 10 mg Injection
7 Myocardial infarction IV 5 10 mg Injection
8 Pain Epidural 5 mg Injection
9 Pain intrathecal 0.2 1 mg Injection As a single dose.
10 Pain intrathecal 0.2 1 mg Injection As a single dose.
11 Acute pulmonary oedema IV 5 10 mg Injection
12 Coughs Oral 5 mg Solution Every 4 hours.

Ref :-  Book : Martindale    Page : 93   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Severe pain > 1 Day > 28 Day SC 100 micrograms/kg Injection q.i.d.
2 Severe pain 1 Month 6 Month SC 100 200 micrograms/kg Injection q.i.d.
3 Severe pain 6 Month 2 Year SC 100 200 micrograms/kg Injection
4 Severe pain 2 Year 12 Year SC 200 micrograms/kg Injection
5 Severe pain 12 Year 18 Year SC 2.5 10 mg Injection
6 Severe pain > 1 Day > 28 Day IV 50 micrograms/kg Injection q.i.d.
7 Severe pain 1 Month 6 Month IV 100 micrograms/kg Injection q.i.d.
8 Severe pain 6 Month 12 Year IV 100 micrograms/kg Injection
9 Severe pain 12 Year 18 Year IV 5 mg
10 Severe pain 1 Month 3 Month Oral 50 100 micrograms/kg Tablet
11 Severe pain 3 Month 6 Month Oral 100 150 micrograms/kg Tablet
12 Severe pain 6 Month 12 Month Oral 200 micrograms/kg Tablet
13 Severe pain 1 Year 12 Year Oral 200 300 micrograms/kg Tablet
14 Severe pain 12 Year 18 Year Oral 5 10 micrograms/kg Tablet
15 Palliative treatment 1 Month 3 Month SC 10 microgram/kg/hour Injection
16 Palliative treatment 3 Month 18 Year SC 20 micrograms/kg/hour Injection
17 Neonatal abstinence syndrome Oral 40 micrograms/kg Tablet

Ref :- Book : Martindale    Page : 94   Edition : 38,
Precaution :- If a Patient is using 'morphine' drug in  dhatura   disease, then Please contraindicated with dhatura poisoning drugs .

►  Side Effect : hallucinations, dyskinesia, abnormal behaviour, nausea, vomiting, QT prolongation, injection-site reactions, development of pattern of abuse,
Ref :-   Book : Goodman    Page : 617   Edition : 12,

►  Drug Interaction : Drug interaction of morphine is with organic nitrates,  Ondansetron ,
Ref :-   Book : Martindale    Page : 879   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  NA


►  Contraindication : respiratory depression, CNS depression, hypersensitivity to opioids, neuropsychiatric problems, dementia, pulmonary disease, cardiovascular disease, Endocrine disease, renal impairment, hepatic impairment,
Ref :-   Book : Martindale    Page : 879   Edition : 37,
  ►  Mechanism of Action :   NA

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Kava with same pathway, Bitter melon with Another pathway,

  ►  Pathway with its reference as follows :-
  • Morphine --- (: kokate, D. & Purohit, A. (2013). pharmacognosy. Abhyudaya pragati: Nirali prakashan. )
  • Exendin 9 have hypoglycemic effect --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- https://www.sapnaonline.com/books/pharmacognosy-ck-kokate-8196396155-9788196396152, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- ELDER with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- MELATONIN with Cause excessive drawsinesss when taken with drug., CANNABIS with Cannabis enhance the effect of morphine ,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand.
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA