sexagliptin is a Medicine belongs to Dipeptidylpeptidase-4 inhibitor/antidiabetic group whose information about Brand can be referenced from   Book : Basic & Clinical pharmacology    Page : 766   Edition : 12,

  ►   Brandname : Onglyza

  ►  Strength : Tablet with 2.5  Mg, Tablet with 5  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 766   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 501   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Type 2 diabetes mellitus Oral 2.5 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 499   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : upper respiratory-tract-infection, headache, peripheral edema, hypoglycemia, hypersensitivity reactions, Urticaria, facial edema,
Ref :-   Book : Basic & Clinical pharmacology    Page : 761   Edition : 12,

►  Drug Interaction : Drug interaction of sexagliptin is with Simvastatin ,
Ref :-   Book : Martindale    Page : 501   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  drugs with alter the activity of the cytochrome P450 isoenzyme cyp3A and cyp3 A5 could affect the metabolism of saxagliptin low dose of saxagliptin should be used when stong inhibitor auch as ketoconazole.the enzyme inducer rifampicin can significantly decrease exposure to saxagliptin,
Ref :-   Book : Martindale    Page : 500   Edition : 37,


►  Contraindication : Type 1 diabetes mellitus, diabetic ketoacidosis,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 539   Edition : 3,
  ►  Mechanism of Action :   sexagliptin is an inhibitor of the enzyme dipeptidylpeptidase-4, enzyme responsible, among other roles, for the degradation of the incretin hormone glucagon-like peptide-1 (GLP-1; insulinotropin), which plays a role in regulating insulin secretion.,
Ref :-   Book : Martindale    Page : 501   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Berries with same pathway,

  ►  Pathway with its reference as follows :-
  • DPP 4 inhibitor --- (Fan, J., Johnson, M., Lila, M., Yousef, G. and de Mejia, E. (2013). Berry and Citrus Phenolic Compounds Inhibit Dipeptidyl Peptidase IV: Implications in Diabetes Management. Evidence-Based Complementary and Alternative Medicine, 2013, pp.1-13. )

  •   ►  URL -- http://www.hindawi.com/journals/ecam/2013/479505/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 761   Edition : 12,


    ►    Plasma Half-life :
      Min value :-   2.5 hours,    Max value :-   NA
    Ref :-   Book : Basic & Clinical pharmacology    Page : 761   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Basic & Clinical pharmacology    Page : 761   Edition : 12,