Medicine :   
Nabilone is a Medicine belongs to Antiemetic group whose properties about Brand can be referenced from   Book : Martindale    Page : 1904   Edition : 37,

  ►   Brandname : Cesamet

  ►  Doseform : Tablet with 1  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1904   Edition : 37,

  ►  Indication/uses : Antiemetic,
Reference :-   Book : Martindale    Page : 1904   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nabilone medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Antiemetic Oral 1 mg Tablet b.d. Dose; Increased to 2 mg twice daily if necessary. The first dose should be given the evening before starting chemotherapy, and the second dose 1 to 3 hours before the first dose of antineoplastic.

Ref :-  Book : Martindale    Page : 1904   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Vomiting Oral 0.05 0.1 mg/kg
2 Vomiting Oral 0.05 0.1 mg/kg

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1244   Edition : 19,
►  Side Effect : drowsiness, vertigo, dry mouth, ataxia, Confusion, disorientation, Dizziness, euphoria, dysphoria, hallucinations, psychoses, Depression, Psychosis, headache, Blurred Vision, Sleep disturbances, hypotension, Orthostatic hypotension, tachycardia, gastrointestinal disturbance, decreased appetite, abdominal pain, decreased concentration, decreased coordination,
Ref :-   Book : Martindale    Page : 1904   Edition : 37,

►  Interaction : Zonisamide , Codeine , Diazepam , Phentolamine ,
Ref :-   Book : Martindale    Page : 1904   Edition : 37,


►  Contraindication : hepatic impairment, psychiatric disorder, depression, hypertension, Heart disease, Because of the possibility of CNS depression, patients should be warned not to drive or operate machinery,
Ref :-   Book : Martindale    Page : 1904   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Nabilone has been shown to have an additive CNS depressant effect when given with alcohol, codeine, diazepam, or other CNS depressants.,
Ref :-   Book : Martindale    Page : 1904   Edition : 37,


  ►  Mechanism of Action :   Nabilone, a synthetic cannabinoid. The exact mechanism of the anti-emetic action is not known but probably relates to stimulation of the CB1 subtype of cannabinoid receptors on neurons in and around the vomiting center in the brainstem,
Ref :-   Book : Goodman    Page : 1345   Edition : 12,
 ►   

Dietary Products that produce same effect as  Nabilone






►   Route of Elimination :   Renal, Biliary, Faecal,
Ref :-   Book : Martindale    Page : 1904   Edition : 37,


►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1904   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA