Medicine :   
Nabumetone is a Medicine belongs to Non Sterodial Anti- Inflammatory Drugs group whose properties about Brand can be referenced from   Book : Martindale    Page : 95   Edition : 37,

  ►   Brandname : Nabuflam,Relifex,Relafen

  ►  Doseform : Tablet with 500  mg, Tablet with 750  mg, Oral solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 656   Edition : 12, Martindale    Page : 95   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 95   Edition : 37,

  ►  Indication/uses : osteoarthritis, Rheumatoid arthiritis,
Reference :-   Book : Martindale    Page : 95   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nabumetone medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Osteoarthritis Oral 1 gm Tablet Taken as a single dose in the evening; if necessary 0.5 to 1 g may be given additionally in the morning.
2 Rheumatoid arthiritis Oral 1 gm Tablet Taken as a single dose in the evening; if necessary 0.5 to 1 g may be given additionally in the morning.

Ref :-  Book : Martindale    Page : 95   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  

Ref :- Book :
►  Side Effect : Gastrointestinal disturbances, gastrointestinal discomfort, nausea, diarrhoea, Peptic Ulceration, severe gastrointestinal bleeding, headache, vertigo, Dizziness, Nervousness, tinnitus, drowsiness, insomnia, hypersensitivity reactions, fever, angioedema, bronchospasm, Rashes, visual disturbances, anaemia, thrombocytopenia, neutropenia, eosinophilia, agranulocytosis, fluid retention, photosensitivity, Induction or exacerbation of colitis, ,
Ref :-   Book : Martindale    Page : 95,100   Edition : 37,

►  Interaction : , Heparin , Mifepristone , Ritonavir, Zidovudine, Pentoxifylline , , , Sibutramine, Erlotinib, Iloprost , Ticlopidine , Clopidogrel , Venlafaxine , , , , , Phenytoin , , , Cyclosporine , , , Methotrexate, ,
Ref :-   Book : Martindale    Page : 95,103   Edition : 37,


►  Contraindication : Severe hepatic impairment,
Ref :-   Book : Martindale    Page : 95   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Interactions involving NSAIDs include enhancement of the effects of oral anticoagulants (especially by azapropazone and phenylbutazone) and increased plasma concentrations of lithium, methotrexate, and cardiac glycosides. The risk of nephrotoxicity may be increased if given with ACE inhibitors, ciclosporin, tacrolimus, or diuretics. Effects on renal function may lead to reduced excretion of some drugs. There may also be an increased risk of hyperkalaemia with ACE inhibitors and some diuretics, including potassiumsparing diuretics. Convulsions may occur due to an interaction with quinolones. NSAIDs may increase the effects of phenytoin and sulfonylurea antidiabetics. The risk of gastrointestinal bleeding and ulceration associated with NSAIDs is increased when used with corticosteroids, the SSRIs, the SNRI venlafaxine, the antiplatelets clopidogrel and ticlopidine, iloprost, erlotinib, sibutramine, or, possibly, alcohol, bisphosphonates, or pentoxifylline. There may be an increased risk of haematotoxicity if zidovudine is used with NSAIDs. Ritonavir may increase the plasma concentrations of NSAIDs. Licensed product information for mifepristone advises of a theoretical risk that prostaglandin synthetase inhibition by NSAIDs or aspirin may alter the efficacy of mifepristone,
Ref :-   Book : Martindale    Page : 95,103   Edition : 37,


  ►  Mechanism of Action :   It is the progdrug of 6-methoxy-2-naphthylactic acid; thus it is a week inhibitor of COX in vitro but a potent COX inhibitor in vivo. ,
Ref :-   Book : Goodman    Page : 986   Edition : 12,
 ►   

Dietary Products that produce same effect as  Nabumetone






►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 95   Edition : 37,


►    Plasma Half-life :   Min value :-   24 hours,    Max value :-   NA
Ref :-   Book : Goodman    Page : 970   Edition : 12,


►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   6 hours,
Ref :-   Book : Goodman    Page : 970   Edition : 12,