Medicine :   
Nafarelin is a Medicine belongs to Gonadotropin agonists group whose properties about Brand can be referenced from   Book : Martindale    Page : 2312   Edition : 37,

  ►   Brandname : Nasarel, Synarel

  ►  Doseform : Solution with 2  mg/ml, Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 677   Edition : 12, Martindale    Page : 2325   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : intranasal, SC,
Reference :-   Book : Martindale    Page : 2325   Edition : 37,

  ►  Indication/uses : endometriosis , Oocyte collection for IVF, Central precocious puberty,
Reference :-   Book : Martindale    Page : 2325   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nafarelin medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Endometriosis intranasal 200 micrograms Solution b.d. Dose: Doubled after 2 months if amenorrhoea has not occurred. Treatment should begin on days 2 to 4 of the menstrual cycle, and may be continued for up to 6 months
2 Oocyte collection for IVF intranasal 400 micrograms Solution b.d. Dose: Beginning either in the early follicular phase (day 2) or midluteal phase (day 21) of the menstrual cycle. Therapy should be continued until downregulation is achieved; if this does not occur within 12 weeks therapy should be withdrawn.

Ref :-  Book : Martindale    Page : 2325   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Central precocious puberty intranasal 800 micrograms Solution

Ref :- Book : Martindale    Page : 2325   Edition : 37,
►  Side Effect : nausea, abdominal pain, abdominal discomfort, headache, lightheadedness, Increase in menstrual bleeding, vaginal dryness, hot flushes, loss of libido, sexual dysfunction, breast swelling, tenderness, hormonal milieu, mood changes, Nervousness, palpitations, acne, dry skin, changes in scalp and body hair, Alterations in liver function tests and blood lipids, decreased glucose tolerance, arthralgia, paraesthesias, Reactions or pain may occur at the site of injection with rash (local or generalised), thrombophlebitis, swelling, pruritus, hypersensitivity reactions, bronchospasm, anaphylaxis, hypercalcaemia, vaginal bleeding,
Ref :-   Book : Martindale    Page : 2313,2325   Edition : 37,

►  Interaction : , , , Levodopa , Spironolactone , , ,
Ref :-   Book : Martindale    Page : 2313,2325   Edition : 37,


►  Contraindication : in patients with pituitary adenoma as haemorrhagic infarction (pituitary apoplexy), weight-related amenorrhoea, Polycystic ovary disease, Endometriotic cysts, Pregnancy,
Ref :-   Book : Martindale    Page : 2313,2325   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Drugs affecting pituitary secretion of gonadotrophins may alter the response to gonadorelin or its analogues; other hormonal therapy and corticosteroids can affect the response. Spironolactone and levodopa can stimulate gonadotrophins while phenothiazines, dopamine antagonists, digoxin, and sex hormones can inhibit gonadotrophin secretion,
Ref :-   Book : Martindale    Page : 2313,2325   Edition : 37,


  ►  Mechanism of Action :   Nafarelin acetate is an analogue of gonadorelin. It stimulates the synthesis and release of follicle-stimulating hormone and, in particular, luteinising hormone in the anterior lobe of the pituitary,
Ref :-   Book : Martindale    Page : 2313,2325   Edition : 37,
 ►   

Dietary Products that produce same effect as  Nafarelin






►   Route of Elimination :   Renal, Faecal,
Ref :-   Book : Martindale    Page : 2325   Edition : 37,


►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   4 hours,
Ref :-   Book : Martindale    Page : 2325   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   20 minutes,    Max value :-   NA
Ref :-   Book : Martindale    Page : 2325   Edition : 37,