Medicine :   
Nalmefene is a Medicine belongs to OPIOID ANTAGONISTS group whose properties about Brand can be referenced from   Book : Basic & Clinical pharmacology    Page : 562   Edition : 12,

  ►   Brandname : Revex

  ►  Doseform : Injection with 0.1  mg/ml, Injection with 1  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 562   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM, SC,
Reference :-   Book : Martindale    Page : 1594   Edition : 37,

  ►  Indication/uses : known or suspected opioid overdosage, reversal of postoperative central depression,
Reference :-   Book : Martindale    Page : 1994   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nalmefene medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Reversal of postoperative central depression IV 250 nanogram/kg Injection Further doses of 250 nanograms/kg may be given at intervals of 2 to 5 minutes until the desired level of opioid reversal is reached; cumulative doses above 1 microgram/kg do not provide additional benefit.
2 Known or suspected opioid overdosage IV 500 micrograms Injection Dose: Given 500 micrograms per 70 kg is recommended, followed by a second dose of 1 mg per 70 kg after 2 to 5 minutes if necessary. If a total dose of 1.5 mg per 70 kg is not effective then additional doses are unlikely to have an effect.

Ref :-  Book : Martindale    Page : 1594   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Opioid overdosage IM or IV 250 500 nanogram/kg Injection

Ref :- Book : Martindale    Page : 1594   Edition : 37,
►  Side Effect : nausea, vomiting, tachycardia, hypertension, fever, Dizziness, abdominal cramp, chills, dysphoria, myalgia, joint pains,
Ref :-   Book : Martindale    Page : 1594   Edition : 37,

►  Interaction : NA

►  Contraindication : physically dependent on opioids, Cardiac disease, cardiotoxic drugs, renal impairment,
Ref :-   Book : Martindale    Page : 1594-1595   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


  ►  Mechanism of Action :   Nalmefene is a specific opioid antagonist that acts competitively at opioid receptors. It is an effective antagonist of opioids that possess agonist or mixed agonistantagonist activity. ,
Ref :-   Book : Martindale    Page : 1594-1595   Edition : 37,
 ►   

Dietary Products that produce same effect as  Nalmefene






►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal,
Ref :-   Book : Martindale    Page : 1594   Edition : 37,


►    Plasma Half-life :   Min value :-   10 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1594   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   nf,    Max value :-   NA
Ref :-   Book :    Page :    Edition : ,