Medicine :   
Naloxone is a Medicine belongs to OPIOID ANTAGONISTS group whose properties about Brand can be referenced from   Book : Martindale    Page : 1596   Edition : 37,

  ►   Brandname : Narcotan,Narcan,Naloselect, Narcant

  ►  Doseform : Injection with 0.02  mg/ml, Injection with 0.4  mg/ml, Injection with 1  mg/ml, Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 562   Edition : 12, Martindale    Page : 1596   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV, SC, Endotracheal,
Reference :-   Book : Martindale    Page : 1595   Edition : 37,

  ►  Indication/uses : Opioid overdosage, Postoperatively to reverse central depression resulting from the use of opioid during surgery, Respiratory depression associated with therapeutic opioid use, Respiratory depression induced by opioid overdose,
Reference :-   Book : Martindale    Page : 1595   Edition : 37, Martindale    Page : 1596   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Naloxone medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Opioid overdosage IV 0.4 2 mg Injection Dose: Repeated if necessary at intervals of 2-3 minutes.
2 Postoperatively to reverse central depression resulting from the use of opioid during surgery IV 100 200 micrograms Injection Dose:(Corresponding to 1.5 to 3 micrograms/kg) given at interval of 2-3 minutes, titrated for each patient in order to obtain an optimum respiratory response while maintaining adequate analgesia.

Ref :-  Book : Martindale    Page : 1595   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Known or suspected opioid overdosage IV 10 micrograms/kg Injection
2 Known or suspected opioid overdosage IV infusion 5 20 microgram/kg/hour Injection
3 Known or suspected opioid overdosage 12 Year 18 Year IV infusion 0.24 1.2 mg Injection
4 Respiratory depression induced by opioid overdose Less than 20 kg IV 100 micrograms/kg Injection
5 Respiratory depression induced by opioid overdose 20 kg or more IV 2 mg Injection
6 Respiratory depression associated with therapeutic opioid use IV 10 20 micrograms/kg Injection
7 Posoperative use IV 5 10 micrograms Injection

Ref :- Book : Martindale    Page : 1595   Edition : 37, Martindale    Page : 1596   Edition : 37,
►  Side Effect : nausea, vomiting, hypotension, hypertension, cardiac arrhythmia, pulmonary edema, seizure,
Ref :-   Book : Martindale    Page : 1595   Edition : 37,

►  Interaction : NA

►  Contraindication : physically dependent on opioids, Cardiac disease, cardiotoxic drugs, renal impairment,
Ref :-   Book : Martindale    Page : 1595   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  nf,
Ref :-   Book :    Page :    Edition : ,


  ►  Mechanism of Action :   Antagonists of µ- opioid receptor, there by blocking endogenous or exogenous opioid effects. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 282   Edition : 3,
 ►   

Dietary Products that produce same effect as  Naloxone






►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 1595   Edition : 37,


►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1595   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
Ref :-   Book : Goodman    Page : 1595   Edition : 37,