Medicine :   
Naltrexone is a Medicine belongs to OPIOID ANTAGONISTS group whose properties about Brand can be referenced from   Book : Martindale    Page : 1598   Edition : 37,

  ►   Brandname : Revia, Nemexin, Nodict, Nalorex, Opizone, Depade, Trexan

  ►  Doseform : Injection with 380  mg, Tablet with 50  Mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 562   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM,
Reference :-   Book : Martindale    Page : 1597   Edition : 37,

  ►  Indication/uses : opioid dependance, alcohol dependence ,
Reference :-   Book : Martindale    Page : 1597   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Naltrexone medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Opioid dependence IV 200 micrograms Injection Naltrexone treatment should not be started until the patient has been detoxified and abstinent from opioids for at least 7 to 10 days because of the risk of acute withdrawal; abstinence should be verified by analysis of the patient’s urine. A naloxone challenge test should then be performed to confirm the absence of opioid dependence.The patient observed for 30 seconds for evidence of withdrawal symptoms; if none occur, a further dose of 600 micrograms is given and the patient observed for 30 minutes. Once a negative naloxone challenge test has been obtained, naltrexone hydrochloride is given orally to maintain abstinence. Treatment may be initiated with a dose of 25 mg.
2 Opioid dependence SC 800 micrograms Injection Dose: Naloxone challenge test with a single dose of 800 micrograms given subcutaneously as an alternative to the intravenous route. Once a negative naloxone challenge test has been obtained, naltrexone hydrochloride is given orally to maintain abstinence. Treatment may be initiated with a dose of 25 mg.
3 Alcohol dependence Oral 50 mg Tablet Dose: given daily as an an adjunct in the management of alcohol dependence
4 Alcohol dependence Modified-release intramuscular injection 380 mg Injection Dose: Given once every 4 weeks

Ref :-  Book : Martindale    Page : 1597   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  

Ref :- Book :
►  Side Effect : Difficulty in sleeping, loss of energy, anxiety, dysphoria, abdominal pain, nausea, vomiting, Reduction in appetite, Joint and muscle pain, Dizziness, constipation, diarrhoea, Skin rashes, Reduced potency, Ejaculatory difficulties, Injection site reactions, including abscesses and tissue necrosis, ,
Ref :-   Book : Martindale    Page : 1596-1597   Edition : 37,

►  Interaction : NA

►  Contraindication : hepatic impairment, Acute hepatitis, Hepatic failure, renal impairment, Naltrexone should be avoided in patients receiving opioids therapeutically, Naltrexone should be stopped at least 48 hours before elective surgery involving opioid analgesia,
Ref :-   Book : Martindale    Page : 1597   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


  ►  Mechanism of Action :   Antagonist of µ-opoid receptor, there by blocking endogenous or exogenous opioid effects,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 282   Edition : 3,
 ►   

Dietary Products that produce same effect as  Naltrexone






►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 1597   Edition : 37,


►    Plasma Half-life :   Min value :-   4 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1597   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1597   Edition : 37,