Medicine :   
Naproxen is a Medicine belongs to Non Sterodial Anti- Inflammatory Drugs group whose properties about Brand can be referenced from   Book : Martindale    Page : 97-98   Edition : 37,

  ►   Brandname : Aleve, Anaprox, Alacetan NNA, Aleve, Dolormin mit Naproxen, Artagen, Easy Dayz, Naprosyn, Xenobid,ArthrosinAleve, Anaprox, Naprelan, Naprosyn, Arthroxen

  ►  Doseform : Tablet with 200  mg, Tablet with 220  mg, Tablet with 250  mg, Tablet with 375  mg, Tablet with 500  mg, Controlled-release tablets with 375  mg, Controlled-release tablets with 550  mg, Delayed- release tablets with 375  mg, Delayed- release tablets with 500  mg, Suspension with 125  mg/5mL, Suppository with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 656   Edition : 12, Martindale    Page : 97   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, rectal,
Reference :-   Book : Martindale    Page : 97   Edition : 37,

  ►  Indication/uses : joint disorders, ankylosing spondylitis, osteoarthritis, Rheumatoid arthiritis, Juvenile idiopathic arthritis, dysmenorrhea, headache, migraine, postoperative pain, Soft-tissue disorders, acute gout, fever,
Reference :-   Book : Martindale    Page : 97   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Naproxen medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Rheumatic disorders Oral 500 mg 1 gm Dose: Given daily either as a single dose or in 2 divided doses.
2 Dysmenorrhea Oral 500 mg followed by 250 mg every 6 to 8 hours, up to a maximum daily dose of 1.25 g on the first day and 1 g thereafter
3 Pain and inflammation in musculoskeletal disorders Oral 500 mg followed by 250 mg every 6 to 8 hours, up to a maximum daily dose of 1.25 g on the first day and 1 g thereafter
4 Acute gout Oral 750 mg followed by 250 mg every 8 hours is used
5 Migraine Oral 750 mg if necessary, this may be followed after at least half an hour by further doses of 250 to 500 mg throughout the day to a total maximum daily dose of 1250 mg.

Ref :-  Book : Martindale    Page : 97   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Juvenile idiopathic arthiritis 2 Year Oral 10 mg/kg
2 Juvenile idiopathic arthiritis 2 Year 18 Year Oral 15 mg/kg
3 Dysmenorrhea 1 Month 18 Year Oral 5 mg/kg
4 Pain and inflammation in musculoskeletal disorders 1 Month 18 Year Oral 5 mg/kg

Ref :- Book : Martindale    Page : 97   Edition : 37,
Precaution :- If a Patient is using 'Naproxen' drug in  acute kidney injury   disease, then Please be avoided .

Precaution :- If a Patient is using 'Naproxen' drug in  auto immune hemolytic anemia  disease, then Please Use with caution .

►  Side Effect : gastrointestinal disturbance, nausea, diarrhoea, headache, vertigo, Dizziness, Nervousness, tinnitus, Depression, drowsiness, insomnia, hypersensitivity reactions, fever, angioedema, bronchospasm, Rashes, visual disturbances, anaemia, thrombocytopenia, neutropenia, eosinophilia, agranulocytosis, fluid retention, photosensitivity, Exacerbation of colitis, ,
Ref :-   Book : Martindale    Page : 97,100   Edition : 37,

►  Interaction : Mifepristone , Ritonavir, Pentoxifylline , , , Sibutramine, Erlotinib, Iloprost , Ticlopidine , Clopidogrel , Venlafaxine , , , , , Phenytoin , , , , Tacrolimus , , , , Methotrexate, , Phenylbutazone, Azapropazone,
Ref :-   Book : Martindale    Page : 97,103   Edition : 37,


►  Contraindication : Active peptic ulceration, severe heart failure, Moderate to severe heart failure, Ischaemic heart diseas, peripheral arterial disease, Cerebrovascular disease, hypertension, Left ventricular failure, Oedema, history of hypersensitivity reactions, History of cardiac failure, and in patients with risk factors for developing heart disease, It should also be used with caution in patients with asthma or allergic disorders,
Ref :-   Book : Martindale    Page : 96,102   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Interactions involving NSAIDs include enhancement of the effects of oral anticoagulants (especially by azapropazone and phenylbutazone) and increased plasma concentrations of lithium, methotrexate, and cardiac glycosides. The risk of nephrotoxicity may be increased if given with ACE inhibitors, ciclosporin, tacrolimus, or diuretics. There may also be an increased risk of hyperkalaemia with ACE inhibitors and some diuretics, including potassiumsparing diuretics. The antihypertensive effects of some antihypertensives including ACE inhibitors, beta blockers, and diuretics may be reduced. NSAIDs may increase the effects of phenytoin and sulfonylurea antidiabetics. The risk of gastrointestinal bleeding and ulceration associated with NSAIDs is increased when used with corticosteroids, the SSRIs, the SNRI venlafaxine, the antiplatelets clopidogrel and ticlopidine, iloprost, erlotinib, sibutramine, or, possibly, alcohol, bisphosphonates, or pentoxifylline. Ritonavir may increase the plasma concentrations of NSAIDs. Licensed product information for mifepristone advises of a theoretical risk that prostaglandin synthetase inhibition by NSAIDs or aspirin may alter the efficacy of mifepristone.,
Ref :-   Book : Martindale    Page : 97,103   Edition : 37,


  ►  Mechanism of Action :   Inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), decreasing the biosynthesis of downstream eicosanoids and thereby limiting the inflammatory response,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 761   Edition : 3,
 ►   

Dietary Products that produce same effect as  Naproxen

  •    Fish oil ,    Ashwagandha, have compounds that have the same effect as Naproxen through an alternate pathway


 ►    Dietary Products that enhance the activity of Naproxen
  • Caraway
  • Cumin



►   Route of Elimination :   Renal, Faecal,
Ref :-   Book : Martindale    Page : 97   Edition : 37,


►    Plasma Half-life :   Min value :-   12 hours,    Max value :-   17 hours,
Ref :-   Book : Martindale    Page : 97   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
Ref :-   Book : Martindale    Page : 97   Edition : 37,