Medicine :   
Naratriptan is a Medicine belongs to 5- HT Agonists group whose properties about Brand can be referenced from   Book : Martindale    Page : 678   Edition : 37,

  ►   Brandname : Naramig,Amerge,Formigran

  ►  Doseform : Tablet with 1  mg, Tablet with 2.5  mg, Oral Suspension with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12, Martindale    Page : 678   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 678   Edition : 37,

  ►  Indication/uses : acute treatment of headache phase of migraine attacks,
Reference :-   Book : Martindale    Page : 678   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Naratriptan medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Headache phase of migraine attacks Oral 1 2.5 mg Tablet If no response is obtained with the initial dose, a second dose should not be taken for the same attack. If symptoms recur after an initial response, the dose may be repeated after an interval of 4 hours, to a maximum of 5 mg in any 24-hour period.

Ref :-  Book : Martindale    Page : 678   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 MIGRAINE HEADACHES Oral 2.5 mg Tablet

Ref :- Book : Nelson's textbook of Pediatrics    Page : 2044   Edition : 19,
►  Side Effect : Dizziness, flushing, weakness, drowsiness, fatigue, nausea, vomiting, dyspnoea, paraesthesias, hypoaesthesia, sensation of heaviness, Pain, tightness, hypotension, bradycardia, tachycardia, palpitations, Raynaud’s syndrome, ischemic colitis, visual disturbances, anaphylaxis, ,
Ref :-   Book : Martindale    Page : 678-679   Edition : 37,

►  Interaction : Rizatriptan , Methysergide, ,
Ref :-   Book : Martindale    Page : 678,780-781   Edition : 37,


►  Contraindication : hepatic impairment, renal impairment, Patients with hypersensitivity to sulfonamides may theoretically exhibit a similar reaction to naratriptan,
Ref :-   Book : Martindale    Page : 678   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Naratriptan and other serotonin (5-HT1) agonists should not be given with ergotamine or related compounds (including methysergide) since there is an increased risk of vasospastic reactions. In addition, a delay is advised before starting a serotonin (5-HT1) agonist in patients who have been receiving ergotamine or related compounds: naratriptan, almotriptan, eletriptan, frovatriptan, rizatriptan, or zolmitriptan should not be given until at least 24 hours after stopping the use of preparations Naratriptan or rizatriptan should not be used with, and for 2 weeks after stopping, an MAOI In the UK licensed product information recommends that the maximum dose of zolmitriptan should be reduced when used with inhibitors of monoamine oxidase type A whereas in the USA it contra-indicates such combinations. There have been rare reports of serotonin syndrome associated with the use of triptan serotonin (5-HT1) agonists with SSRIs or serotonin and noradrenaline reuptake inhibitors,
Ref :-   Book : Martindale    Page : 678,680-681   Edition : 37,


  ►  Mechanism of Action :   It is a selective serotonin agonist that acts at 5-HT1 receptors and produces vasoconstriction of cranial arteries.,
Ref :-   Book : Martindale    Page : 678,681   Edition : 37,
 ►   

Dietary Products that produce same effect as  Naratriptan






►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 678   Edition : 37,


►    Plasma Half-life :   Min value :-   6 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 678   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours,
Ref :-   Book : Martindale    Page : 678   Edition : ,