Medicine :   
Nateglinide is a Medicine belongs to Antidiabetic group whose properties about Brand can be referenced from   Book : Martindale    Page : 494   Edition : 37,

  ►   Brandname : Glinate,Starlix

  ►  Doseform : Tablet with 60  mg, Tablet with 120  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 766   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 766   Edition : 12,

  ►  Indication/uses : type 2 diabetes mellitus,
Reference :-   Book : Martindale    Page : 494   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nateglinide medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Type 2 diabetes mellitus Oral 60 120 mg Tablet t.i.d. Dose: It is given within the 30 minutes before meals. This may be increased to 180 mg three times daily if necessary.

Ref :-  Book : Martindale    Page : 494   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Type 2 diabetes mellitus Oral 360 mg Tablet

Ref :- Book : Nelson's textbook of Pediatrics    Page : 2044   Edition : 19,
►  Side Effect : abdominal pain, diarrhoea, constipation, nausea, vomiting, Hypoglycaemia (usually mild), back pain, Joint pain, ,
Ref :-   Book : Martindale    Page : 794,496   Edition : 37,

►  Interaction : , , , , Sulfinpyrazone, Ranitidine , , Heparin , , , , Clarithromycin , Cimetidine , Chloramphenicol , Miconazole, Ketoconazole , Fluconazole , , Phenylbutazone, Azapropazone, Allopurinol , , , , , Rifamycin, , Diazoxide , , Chlorpromazine , aminoglutethimide , Epinephrine (adrenaline) ,
Ref :-   Book : Martindale    Page : 494,503   Edition : 37,


►  Contraindication : hepatic impairment,
Ref :-   Book : Martindale    Page : 494,496   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  As with other oral antidiabetics, the efficacy of nateglinide may be affected by drugs independently increasing or decreasing blood glucose concentrations. A reduced hypoglycaemic effect, possibly requiring an increased dose of sulfonylurea, has been seen or might be expected on theoretical grounds with adrenaline, aminoglutethimide, chlorpromazine, corticosteroids, diazoxide, oral contraceptives, rifamycins, thiazide diuretics, and thyroid hormones. An increased hypoglycaemic effect has occurred or might be expected with ACE inhibitors, alcohol, allopurinol, some analgesics (notably azapropazone, phenylbutazone, and the salicylates), azole antifungals (fluconazole, ketoconazole, and miconazole), chloramphenicol, cimetidine, clofibrate and related compounds, coumarin anticoagulants, fluoroquinolones, heparin, MAOIs, octreotide (although this may also produce hyperglycaemia), ranitidine, sulfinpyrazone, sulfonamides (including co-trimoxazole), tetracyclines, and tricyclic antidepressants. ,
Ref :-   Book : Martindale    Page : 494,503   Edition : 37,


  ►  Mechanism of Action :   Nateglinide a D – phenylalanine derivative and it stimulates very rapid and transient release of insulin from beta cell through closure of ATP sensitive K+ channel,
Ref :-   Book : Basic & Clinical pharmacology    Page : 756   Edition : 12,
 ►   

Dietary Products that produce same effect as  Nateglinide






►   Route of Elimination :   Renal, Faecal,
Ref :-   Book : Martindale    Page : 494   Edition : 37,


►    Plasma Half-life :   Min value :-   1.5 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 494   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 494   Edition : 37,