Medicine :   
Neomycin is a Medicine belongs to Antibacterials group whose properties about Brand can be referenced from   Book : Martindale    Page : 332   Edition : 37,

  ►   Brandname : Neosulf, Cysto-Myacyne N, Myacyne, Nivemycin, Mycifradin, Neo-fradin

  ►  Doseform : Tablet with 500  mg, Eye Drop with   , Eye ointment with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 828   Edition : 12, Martindale    Page : 332   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical,
Reference :-   Book : Martindale    Page : 332   Edition : 37,

  ►  Indication/uses : infections of the skin, ear, and eye due to susceptible staphylococci and other organisms, Pre-operative use, hepatic encephalopathy, Chronic hepatic insufficiency, antibacterial,
Reference :-   Book : Martindale    Page : 332   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Neomycin medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Pre-operative use Oral 1 gm Tablet Dose: As an adjunct: Given hourly for 4 hours and then every 4 hours for 2 or 3 days before surgery.
2 Hepatic encephalopathy Oral 4 12 gm Tablet Dose: As an adjunct: Given daily in divided doses, usually for 5 to 7 days.
3 Chronic hepatic insufficiency Oral Up to 4 gm Tablet Dose: Given daily.
4 Topical 0.35 %

Ref :-  Book : Martindale    Page : 332   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 6 Year 12 Year Oral 250 500 mg Tablet
2 12Year Oral 1 gm Tablet
3 Hepatic encephalopathy Oral 50 100 mg/kg Tablet

Ref :- Book : Martindale    Page : 330   Edition : 38,
Precaution :- If a Patient is using 'Neomycin' drug in nephrotic syndrome disease, then Please not be used   if he ever suffered from chronic kidney disease disease.
►  Side Effect : nausea, vomiting, diarrhoea, severe malabsorption syndrome, steatorrhoea, nephrotoxic, neuromuscular-blocking Action, respiratory depression, fatality, hypersensitivity reactions, Rashes, pruritus, anaphylaxis, drug fever, Cumulative ototoxicity, Hearing loss, Vestibular damage, Reversible nephrotoxicity, Acute renal failure, Decreased glomerular filtration rate, Electrolyte disturbances (notably hypomagnesaemia, but also hypocalcaemia and hypokalaemia), muscular paralysis, death, blood dyscrasias, purpura, stomatitis, Increased serum-aminotransferase values, Increased serum-bilirubin concentrations, neurotoxicity, encephalopathy, Confusion, lethargy, hallucinations, Convulsions, mental depression, ,
Ref :-   Book : Martindale    Page : 306,332   Edition : 37,

►  Interaction : Acarbose , , Methotrexate, Digoxin , Phenoxymethylpenicillin , , Zalcitabine, Dimenhydrinate , Furosemide , Etacrynic acid, Fludarabine, Cisplatin , , , Vancomycin , ,
Ref :-   Book : Martindale    Page : 307,332   Edition : 37,


►  Contraindication : History of hypersensitivity to it, and probably in those hypersensitive to other aminoglycosides, It should be avoided in patients with myasthenia gravis, and great care is required in patients with parkinsonism and other conditions characterised by muscular weakness., Infants under 1 year , It should be used with great care in patients with renal or hepatic impairment, or with neuromuscular disorders, and in those with impaired hearing, The topical use of neomycin in patients with extensive skin damage or perforated tympanic membranes may result in deafness,
Ref :-   Book : Martindale    Page : 307,332   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Use of other nephrotoxic drugs including other aminoglycosides, vancomycin, some cephalosporins, ciclosporin, cisplatin, and fludarabine or of potentially ototoxic drugs such as etacrynic acid and perhaps furosemide, may increase the risk of aminoglycoside toxicity. It has been suggested that use of an antiemetic such as dimenhydrinate may mask the early symptoms of vestibular ototoxicity. The neuromuscular-blocking properties of aminoglycosides may be sufficient to provoke severe respiratory depression in patients given general anaesthetics or opioids. There is a theoretical possibility that the antibacterial effects of aminoglycosides could be reduced by bacteriostatic antibacterials, but such combinations have been used successfully in practice. Renal excretion of zalcitabine may be reduced by aminoglycosides. Neomycin may inhibit α-galactosidase activity and should not be used with agalsidase alfa or beta. Neomycin orally has been reported to impair the absorption of other drugs including phenoxymethylpenicillin, digoxin, and methotrexate; the efficacy of oral contraceptives might be reduced. The effects of acarbose may be enhanced by oral neomycin,
Ref :-   Book : Martindale    Page : 307,332   Edition : 37,


  ►  Mechanism of Action :   Bind to 16S rRNA of the 30S ribosomal subunit and elicit concentration-dependent effects on protein synthesis. Aminoglucosidase are bactericidal, evidently due to induction of mRNA misreading; misread mRNA causes synthesis of aberrant proteins that may activate oxidative stress pathways and/or inert into the cell membrane, forming pores that eventually lead to cell death.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 596   Edition : 3,
 ►   

Dietary Products that produce same effect as  Neomycin

  •    Garlic , have compounds that have the same effect as Neomycin through an alternate pathway



 ►    Neomycin can cause a  'Vitamin A '  deficiency. Neomycin can cause a  'vitamin D'  deficiency. Neomycin can cause a  'Vitamin E'  deficiency. Neomycin can cause a  'Vitamin K'  deficiency. Neomycin can cause a  'Betacarotene'  deficiency. Neomycin can cause a  'Vitamin B12'  deficiency. Neomycin can cause a  'Potassium '  deficiency. Neomycin can cause a  'Calcium'  deficiency. Neomycin can cause a  'Iron'  deficiency. Neomycin can cause a  ''  deficiency.
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 ►   
►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 332   Edition : 37,


►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   3 hours,
Ref :-   Book : Martindale    Page : 332   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA