Medicine :   
Netilmicin is a Medicine belongs to Antibacterials group whose properties about Brand can be referenced from   Book : Martindale    Page : 334   Edition : 37,

  ►   Brandname : Netromycin,Netspan,Certomycin, Netillin

  ►  Doseform : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 334   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, IV,
Reference :-   Book : Martindale    Page : 334   Edition : 37,

  ►  Indication/uses : Severe systemic infections due to sensitive Gram-negative and other organisms. Such infections include abscesses, biliary-tract infections (acute cholecystitis or cholangitis), brucellosis, cat scratch disease, cystic fibrosis, endocarditis (treatment and prophylaxis of endocarditis due to streptococci, enterococci, or staphylococci), endometritis, gastroenteritis, granuloma inguinale, listeriosis, , meningitis, otitis externa, otitis media, pelvic inflammatory disease, peritonitis, plague, pneumonia, septicaemia, skin infections such as in burns or ulcers, trench fever, tularaemia, and urinary-tract infections (acute pyelonephritis),, prophylaxis of surgical infection and the treatment of immunocompromised patients and those in intensive care. It may be used as a multi-drug regimen for the treatment of inhalation and gastrointestinal anthrax.,
Reference :-   Book : Martindale    Page : 308,334   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Netilmicin medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Antibacterial IM 4 6 mg/kg Injection Daily as a single dose; alternatively, it may be given in equally divided doses every 8 or 12 hours;
2 Life-threatening infections IM up to 7.5 mg Injection Dose: given daily in divided doses every 8 hours for short periods.
3 Life-threatening infections slow i.v up to 7.5 mg/kg Injection Dose: Given over 3 to 5 minutes.
4 Life-threatening infections IV infusion up to 7.5 mg/kg Injection Dose: Given over 0.5 to 2 hours in 50 - 200 mL of infusion fluid.

Ref :-  Book : Martindale    Page : 334   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Antibacterial IV infusion 7.5 9 mg/kg/day Injection
2 Antibacterial 6 7.5 mg/kg/day Injection
3 Antibacterial 3 mg/kg Injection

Ref :- Book : Martindale    Page : 334   Edition : 37,
►  Side Effect : Cumulative ototoxicity, Hearing loss, Vestibular damage, Reversible nephrotoxicity, Acute renal failure, Decreased glomerular filtration rate, Electrolyte disturbances (notably hypomagnesaemia, but also hypocalcaemia and hypokalaemia), muscular paralysis, death, blood dyscrasias, purpura, nausea, vomiting, stomatitis, Increased serum-aminotransferase values, Increased serum-bilirubin concentrations, neurotoxicity, encephalopathy, Confusion, lethargy, hallucinations, Convulsions, mental depression, ,
Ref :-   Book : Martindale    Page : 306,333   Edition : 37,

►  Interaction : , Vancomycin , , , Cisplatin , Fludarabine, Etacrynic acid, Furosemide , Dimenhydrinate , Zalcitabine, ,
Ref :-   Book : Martindale    Page : 307,333   Edition : 33, Martindale    Page : 307,333   Edition : 37,


►  Contraindication : Hypersensitivity, myasthenia gravis, parkinsonism, muscle weakness, pregnancy, ototoxicity, nephrotoxicity,
Ref :-   Book : Martindale    Page : 306,307   Edition : 38,
  ►    Mechanism of Drug Drug Interaction :  Use of other nephrotoxic drugs including other aminoglycosides, vancomycin, some cephalosporins, ciclosporin, cisplatin, and fludarabine or of potentially ototoxic drugs such as etacrynic acid and perhaps furosemide, may increase the risk of aminoglycoside toxicity. It has been suggested that use of an antiemetic such as dimenhydrinate may mask the early symptoms of vestibular ototoxicity. The neuromuscular-blocking properties of aminoglycosides may be sufficient to provoke severe respiratory depression in patients given general anaesthetics or opioids. There is a theoretical possibility that the antibacterial effects of aminoglycosides could be reduced by bacteriostatic antibacterials, but such combinations have been used successfully in practice. Renal excretion of zalcitabine may be reduced by aminoglycosides. Neomycin may inhibit α-galactosidase activity and should not be used with agalsidase alfa or beta.,
Ref :-   Book : Martindale    Page : 307,333   Edition : 37,


  ►  Mechanism of Action :   Bind to 16S rRNA of the 30S ribosomal subunit and elicit concentration-dependent effects on protein synthesis. Aminoglycosides are bactericidal, evidently due to induction of mRNA misreading; misread mRNA causes synthesis of aberrant proteins that may activate oxidative stress pathways and/or insert into the cell membrane, forming pores that eventually lead to cell death,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 596   Edition : 3,
 ►   

Dietary Products that produce same effect as  Netilmicin






►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 334   Edition : 37,


►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   2.5 hours,
Ref :-   Book : Martindale    Page : 334   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   1 hours,
Ref :-   Book : Martindale    Page : 333   Edition : 37,