Medicine :   
Nevirapine is a Medicine belongs to Antiviral group whose properties about Brand can be referenced from   Book : Martindale    Page : 994   Edition : 37,

  ►   Brandname : Viramune, Neve, Nevimune

  ►  Doseform : Tablet with 200  mg, Suspension with 50/5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 993   Edition : 37,

  ►  Indication/uses : HIV infection and AIDS,
Reference :-   Book : Martindale    Page : 993   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nevirapine medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 HIV infection and AIDS Oral 200 mg Tablet o.d. Dose: Given for the first 14 days, then increased to 200 mg twice daily provided that no rash is present.

Ref :-  Book : Martindale    Page : 993   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 HIV infection 15 Day 8 Year Oral 4 mg/kg
2 HIV infection 8 Year 16 Year Oral 4 mg/kg

Ref :- Book : Martindale    Page : 994   Edition : 37,
►  Side Effect : Skin rashes, skin rash (usually mild to moderate, maculopapular, erythematous, and sometimes pruritic), Stevens-Johnson syndrome, hypersensitivity reactions, angioedema, Urticaria, anaphylaxis, fever, arthralgia, myalgia, lymphadenopathy, eosinophilia, granulocytopenia, hepatitis, hepatic necrosis, rhabdomyolysis, nausea, vomiting, diarrhoea, abdominal pain, fatigue, drowsiness, central obesity, peripheral wasting, facial wasting, breast enlargement, Cushingoid symptom, hypertriglyceridaemia, hypercholesterolaemia, insulin resistance, Hyperglycaemia, Hyperlactataemia, Osteonecrosis, ,
Ref :-   Book : Martindale    Page : 992   Edition : 37,

►  Interaction : Rifampicin , ,
Ref :-   Book : Martindale    Page : 993   Edition : 37,


►  Contraindication : hepatic impairment, Patients taking nevirapine should be closely monitored for adverse skin reactions and hepatotoxicity, Treatment should be permanently stopped in patients who suffer a severe rash, rash accompanied by constitutional symptoms (such as fever, blistering, oral lesions, conjunctivitis, facial oedema, muscle or joint aches, or general malaise), hypersensitivity reactions, or clinical hepatitis,
Ref :-   Book : Martindale    Page : 993   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Nevirapine is metabolised mainly by the cytochrome P450 isoenzymes CYP3A4 and CYP2B6. Consequently it may compete with other drugs metabolised by this system, possibly resulting in mutually increased plasma concentrations and toxicity. Alternatively, enzyme inducers may decrease plasma concentrations of nevirapine; nevirapine itself acts as a mild to moderate enzyme inducer and may thus reduce plasma concentrations of other drugs. Rifampicin and St John’s wort decrease the concentration of nevirapine; use with the antiretroviral is not recommended due to the possible loss of its activity and development of resistance.,
Ref :-   Book : Martindale    Page : 993   Edition : 37,


  ►  Mechanism of Action :   Nevirapine acts by non-competitive inhibition of HIV- 1 reverse transcriptase; it binds to the enzyme, disrupting the conformation of its catalytic site and impairing its RNA- and DNA-dependent polymerase activity,
Ref :-   Book : Martindale    Page : 993   Edition : 37,
 ►   

Dietary Products that produce same effect as  Nevirapine






►   Route of Elimination :   Biliary,
Ref :-   Book : Martindale    Page : 992   Edition : 37,


►    Plasma Half-life :   Min value :-   25 hours,    Max value :-   30 hours,
Ref :-   Book : Goodman    Page : 1642   Edition : 12,


►    Peak Plasma Concentration :   Min value :-   4 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 992   Edition : 37,