Medicine :   
Niacin is a Medicine belongs to group whose properties about Brand can be referenced from   Book : Martindale    Page : 2119   Edition : 37,

  ►   Brandname : Endur-acin,Niaspan,Nialip

  ►  Doseform : Tablet with 100  mg, Tablet with 250  mg, Tablet with 500  mg, Tablet with 1000  mg, Tablet (Extended Release Tablets) with 750  mg, Tablet (Extended Release Tablets) with 500  mg, Tablet (Extended Release Tablets) with 1000  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 633   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, IV, Topical,
Reference :-   Book : Martindale    Page : 2119   Edition : 38, Martindale    Page : 2119   Edition : 37,

  ►  Indication/uses : NA
Dosing of Medicine differ in Adult & Pediatrics ↓


► Niacin medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info

Ref :-  Book :




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  

Ref :- Book :
►  Side Effect : flushing, sensation of heat, faintness, pounding in the head, Dizziness, tachycardia, palpitations, dyspnoea, sweating, chills, oedema, dryness of the skin, pruritus, erythema, burning sensation, Irritation, hyperpigmentation, cramp, diarrhoea, nausea, vomiting, anorexia, activation of peptic ulcer, amblyopia, jaundice, impairment of liver function, decrease in glucose tolerance, Hyperglycaemia, hyperuricaemia, hypophosphataemia, reduction in platelet counts, prolongation of prothrombin time, arrhythmia, angioedema, insomnia, myalgia, hypotension,
Ref :-   Book : Martindale    Page : 2083,2084   Edition : 38,

►  Interaction : Insulin , Insulin , Aspirin, Colestipol , Cholestyramine ,
Ref :-   Book : Martindale    Page : 2084   Edition : 37,


►  Contraindication : Diabetes mellitus, peptic ulcer disease, hepatic impairment,
Ref :-   Book : Martindale    Page : 2118   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Nicotinic acid may increase the requirements for insulin or oral hypoglycaemics. Aspirin may reduce the clearance of nicotinic acid. In vitro studies suggest that colestipol and colestyramine may reduce the availability of nicotinic acid.,
Ref :-   Book : Martindale    Page : 2118   Edition : 37,


  ►  Mechanism of Action :   Reduces free fatty acid release from adipose tissue; increases plasma residence time for apoA1. Triglyceride decrease up to 45%; LDL decreases up to 20%; HDL increases up to 30%,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 331   Edition : 3,
 ►   

Dietary Products that produce same effect as  Niacin

  •    Peanut, have compounds that have the same effect as Niacin through an alternate pathway





►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Goodman    Page : 900   Edition : 12,


►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   NA
Ref :-   Book : Goodman    Page : 900   Edition : 12,


►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   1 hours,
Ref :-   Book : Goodman    Page : 900   Edition : 12,