Medicine :   
Nicardipine is a Medicine belongs to Cardiovascular drugs group whose properties about Brand can be referenced from   Book : Martindale    Page : 1481   Edition : 37, Basic & Clinical pharmacology    Page : 209   Edition : 12,

  ►   Brandname : Cardene,Cardene SR, Cardene I.V

  ►  Doseform : Capsule with 20  mg, Capsule with 30  mg, Capsule with 60  mg, Sustained-release capsules with 30  mg, Sustained-release capsules with 45  mg, Sustained-release capsules with 60  mg, Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 209   Edition : 12, Martindale    Page : 1481   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1481   Edition : 37,

  ►  Indication/uses : hypertension, angina, hypertensive crises,
Reference :-   Book : Martindale    Page : 1481   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nicardipine medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 hypertension Oral 20 mg Capsule t.i.d. Dose may be increased at intervals of at least 3 days until the required effect is achieved. The usual maintenance dose is 30 mg three times daily, but daily doses of between 60 and 120 mg in divided doses may be given.
2 Angina Oral 20 mg Capsule t.i.d. Dose may be increased at intervals of at least 3 days until the required effect is achieved. The usual maintenance dose is 30 mg three times daily, but daily doses of between 60 and 120 mg in divided doses may be given.
3 hypertension Slow IV infusion 100 mcg/ml Injection An initial infusion rate of 5 mg/hour is recommended, increased, as necessary, up to a maximum of 15 mg/hour and subsequently reduced to 3 mg/hour
4 Angina Slow IV infusion 100 mcg/ml Injection An initial infusion rate of 5 mg/hour is recommended, increased, as necessary, up to a maximum of 15 mg/hour and subsequently reduced to 3 mg/hour

Ref :-  Book : Martindale    Page : 1481   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Hypertensive crises continuous i.v infusion 500 nanograms/kg per minute Injection

Ref :- Book : Martindale    Page : 1481   Edition : 37,
►  Side Effect : Dizziness, flushing, headache, hypotension, peripheral oedema, tachycardia, palpitations, nausea, constipation, Other gastrointestinal disturbances, increased micturition frequency, lethargy, eye pain, visual disturbances, syncope, vertigo, migraine, mood disturbances, Rashes, erythema multiforme, fever, abnormalities in liver function, cholestasis, hypersensitivity reactions, gingival hyperplasia, pruritus, myalgia, tremor, Gynaecomastia,
Ref :-   Book : Martindale    Page : 1480,1482   Edition : 37,

►  Interaction : , Aldesleukin , , Quinidine , Carbamazapine , Phenytoin , Rifampicin , Cimetidine , Erythromycin , ,
Ref :-   Book : Martindale    Page : 1481,1485   Edition : 37,


►  Contraindication : It should be used with caution in patients with hypotension, in patients whose cardiac reserve is poor, and in those with heart failure since deterioration of heart failure has been noted., It should not be used in cardiogenic shock, in patients who have suffered a myocardial infarction in the previous 2 to 4 weeks, or in acute unstable angina., It should not be used to treat an anginal attack in chronic stable angina, nor should it be used for the acute reduction of blood pressure in adults, though it may be used for this purpose in children, In patients with severe aortic stenosis nifedipine may increase the risk of developing heart failure., The consumption of alcohol should be avoided on the day of treatment and for 1 day afterward., The safety of the drug has not been established in pregnancy or for children younger than 2 years of age.,
Ref :-   Book : Martindale    Page : 1480,1485   Edition : 37, Basic & Clinical pharmacology    Page : 943   Edition : 12,
  ►    Mechanism of Drug Drug Interaction :  Nicardipine may enhance the antihypertensive effects of other antihypertensive drugs such as beta blockers although the combination is generally well tolerated. Enhanced antihypertensive effects may also be seen if used with drugs such as aldesleukin and antipsychotics that cause hypotension. Nicardipine may modify insulin and glucose responses and therefore diabetic patients may need to adjust their antidiabetic treatment when receiving nicardipine. Nicardipine is extensively metabolised in the liver by the cytochrome P450 isoenzyme CYP3A4, and interactions may occur with other drugs, such as quinidine, sharing the same metabolic pathway, and with enzyme inducers, such as carbamazepine, phenytoin, and rifampicin, and enzyme inhibitors, such as cimetidine, erythromycin, and HIVprotease inhibitors.,
Ref :-   Book : Martindale    Page : 1481,1485   Edition : 37,


  ►  Mechanism of Action :   Nicardipine is a dihydropyridine calcium-channel blocker. It Inhibit the cellular influx of calcium that is responsible for maintenance of the plateau phase of the action potential. Thus calciumchannel blockers primarily affect tissues in which depolarisation is dependent upon calcium rather than sodium influx, such as vascular smooth muscle, myocardial cells, and cells within the sino-atrial (SA) and atrioventricular (AV) nodes. The main actions of the calcium-channel blockers include dilatation of coronary and peripheral arteries and arterioles with little or no effect on venous tone, a negative inotropic action, reduction of heart rate, and slowing of AV conduction.,
Ref :-   Book : Martindale    Page : 1270,1481,1487   Edition : 37,
 ►   

Dietary Products that produce same effect as  Nicardipine

  •    Ginger (Zingiber officinale), compounds that act on the same pathway as Nicardipine
  •    Garlic , have compounds that have the same effect as Nicardipine through an alternate pathway





►   Route of Elimination :   Faecal, Hepatic (Metabolism),
Ref :-   Book : Martindale    Page : 1481   Edition : 37,


►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA