Medicine :   
Nifedipine is a Medicine belongs to Cardiovascular drugs group whose properties about Brand can be referenced from   Book : Martindale    Page : 1490   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Adalat,Afeditab,Nifediac,Nifedical,Procardia,Adipine, Angiopine, Calchan, Cardilate MR,Nifehexal, Nyefax, Calcigard, Calnif, Cardules,Nicardia Retard

  ►  Doseform : Capsule with 10  mg, Capsule with 20  mg, Extended- release tablets with 30  mg, Extended- release tablets with 60  mg, Extended- release tablets with 90  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 209   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, sublingual,
Reference :-   Book : Martindale    Page : 1487   Edition : 37, Martindale    Page : 1483   Edition : 37,

  ►  Indication/uses : hypertension, angina pectoris, Raynaud’s syndrome, Hypertension; angina in Kawasaki disease or progeria, Hypertensive crises: acute angina in Kawasaki disease or progeria, Neonatal hyperinsulinaemic hypoglycaemia,
Reference :-   Book : Martindale    Page : 1487   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nifedipine medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 hypertension Oral 10 40 mg b.d. Or 20 to 90 mg once daily, depending on the preparation used
2 Angina pectoris Oral 10 40 mg b.d. Or 30 to 90 mg once daily
3 Angina pectoris Oral 5 20 mg Capsule t.i.d.
4 Raynaud’s syndrome Oral 5 20 mg Capsule t.i.d.

Ref :-  Book : Martindale    Page : 1487   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Hypertension; angina in Kawasaki disease or progeria 1 Month 12 Year Oral 200 300 mcg/kg
2 Hypertension; angina in Kawasaki disease or progeria 12 Year 18 Year Oral 5 20 mg
3 Hypertensive crises: acute angina in Kawasaki disease or progeria 1 Month 18 Year Oral 250 500 mcg/kg
4 Raynaud’s syndrome 2 Year 18 Year Oral 2.5 10 mg

Ref :- Book : Martindale    Page : 1487   Edition : 37,
Precaution :- If a Patient is using 'Nifedipine' drug in  acute myocardial infarction  disease, then Please be used with caution .

Precaution :- If a Patient is using 'Nifedipine' drug in  Preterm labor  disease, then Please Precaution: cardiogenic shock, coronary artery disease .

Precaution :- If a Patient is using 'Nifedipine' drug in  intracranial hypertension  disease, then Please as it increases ICT .

►  Side Effect : Dizziness, flushing, headache, hypotension, peripheral oedema, tachycardia, palpitations, nausea, gastrointestinal disturbance, increased micturition frequency, lethargy, eye pain, visual disturbances, syncope, vertigo, migraine, mood disturbances, Rashes, erythema multiforme, fever, abnormalities in liver function, hypersensitivity reactions, gingival hyperplasia, myalgia, tremor, impotence, gastrointestinal obstruction, constipation, pruritus,
Ref :-   Book : Martindale    Page : 1482,1483   Edition : 37, Martindale    Page : 482,1483    Edition : 37,

►  Interaction : , Aldesleukin , , Quinidine , Carbamazapine , Phenytoin , Rifampicin , Cimetidine , Erythromycin , ,
Ref :-   Book : Martindale    Page : 1485   Edition : 37,


►  Contraindication : It should be used with caution in patients with hypotension, in patients whose cardiac reserve is poor, and in those with heart failure since deterioration of heart failure has been noted., It should not be used in cardiogenic shock, in patients who have suffered a myocardial infarction in the previous 2 to 4 weeks, or in acute unstable angina., It should not be used to treat an anginal attack in chronic stable angina, nor should it be used for the acute reduction of blood pressure in adults, though it may be used for this purpose in children, In patients with severe aortic stenosis nifedipine may increase the risk of developing heart failure.,
Ref :-   Book : Martindale    Page : 1485   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Nifedipine may enhance the antihypertensive effects of other antihypertensive drugs such as beta blockers although the combination is generally well tolerated. Enhanced antihypertensive effects may also be seen if used with drugs such as aldesleukin and antipsychotics that cause hypotension. Nifedipine may modify insulin and glucose responsese and therefore diabetic patients may need to adjust their antidiabetic treatment when receiving nifedipine. Nifedipine is extensively metabolised in the liver by the cytochrome P450 isoenzyme CYP3A4, and interactions may occur with other drugs, such as quinidine, sharing the same metabolic pathway, and with enzyme inducers, such as carbamazepine, phenytoin, and rifampicin, and enzyme inhibitors, such as cimetidine, erythromycin, and HIVprotease inhibitors.,
Ref :-   Book : Martindale    Page : 1485   Edition : 37,


  ►  Mechanism of Action :   Nifedipine is a dihydropyridine calcium-channel blocker. It is a peripheral and coronary vasodilator, but, unlike the rate-limiting calcium-channel blockers verapamil or diltiazem, has little or no effect on cardiac conduction and negative inotropic activity is rarely seen at therapeutic doses. Use of nifedipine results primarily in vasodilatation, with reduced peripheral resistance, blood pressure, and afterload, increased coronary blood flow, and a reflex increase in heart rate. This in turn results in an increase in myocardial oxygen supply and cardiac output.,
Ref :-   Book : Martindale    Page : 1486   Edition : 37,
 ►   

Dietary Products that produce same effect as  Nifedipine

  •    Ginger (Zingiber officinale), compounds that act on the same pathway as Nifedipine
  •    Sunflower seed , have compounds that have the same effect as Nifedipine through an alternate pathway


 ►    Dietary Products that enhance the activity of Nifedipine
  • Vitamin C
  • Glucosides
  • Fat
  • Nondigestible Fiber
  • Epigallocatechin gallate


 ►    'Ginkgo biloba '  should be taken regularly when taking  Nifedipine 'Grape fruit juice '  should be taken regularly when taking  Nifedipine
 ►   
►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal,
Ref :-   Book : Martindale    Page : 1486   Edition : 37,


►    Plasma Half-life :   Min value :-   2 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1486   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   30 minutes,    Max value :-   60 minutes,
Ref :-   Book : Martindale    Page : 1486   Edition : 37,