Medicine :   
Nifurtimox is a Medicine belongs to Antiprotozoals group whose properties about Brand can be referenced from   Book : Martindale    Page : 929   Edition : 37,

  ►   Brandname : Lampit

  ►  Doseform : Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 929   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 929   Edition : 37,

  ►  Indication/uses : American trypanosomiasis (Chagas’ disease),
Reference :-   Book : Martindale    Page : 929   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nifurtimox medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 American trypanosomiasis (Chagas’ disease) Oral 8 10 mg/kg/day Tablet Dose: 3 to 4 divided doses given for 90 days for acute infections and 120 days for chronic infections.

Ref :-  Book : Martindale    Page : 929   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 American trypanosomiasis (Chagas’ disease) 1 Year 10 Year Oral 15 20 mg/kg
2 American trypanosomiasis (Chagas’ disease) 11 Year 16 Year Oral 12.5 15 mg/kg

Ref :- Book : Martindale    Page : 929   Edition : 37,
►  Side Effect : gastrointestinal effects, anorexia, abdominal pain, nausea, vomiting, Memory loss, insomnia, CNS excitement, Psychotic behavior, tremor, muscle weakness, Mild paraesthesia, polyneuropathy, Haematological adverse effects, Skin rashes, allergic reactions,
Ref :-   Book : Martindale    Page : 929   Edition : 37,

►  Interaction : NA

►  Contraindication : Hypersensitivity,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 647   Edition : 3,
  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


  ►  Mechanism of Action :   Nifurtimox activated by a NADH- dependent mitochondrial nitroreductase, leading to the intracellular generation of nitro radical anions that are thought to account for the trypanocidal effect. The generated nitro anion radical from covalent attachments to macromolecules leading to cellular damage that kills the parasites.,
Ref :-   Book : Goodman    Page : 1432   Edition : 12,
 ►   

Dietary Products that produce same effect as  Nifurtimox



 ►    Dietary Products that enhance the activity of Nifurtimox
  • Piperine
  • Ginger (Zingiber officinale)
  • Caraway
  • Cumin
  • Lysergol
  • Fenugreek seed
  • cashew nut tree (Anacardium occidentale)
 ►    Dietary Products that inhibitthe the activity of Nifurtimox
  • Epigallocatechin 3-gallate (EGCG)



►   Route of Elimination :   Renal,
Ref :-   Book : Goodman    Page : 1432   Edition : 12,


►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   NA
Ref :-   Book : Goodman    Page : 1432   Edition : 12,


►    Peak Plasma Concentration :   Min value :-   3.5 hours,    Max value :-   NA
Ref :-   Book : Goodman    Page : 1432   Edition : 12,