Medicine :   
Nimesulide is a Medicine belongs to Non Sterodial Anti- Inflammatory Drugs group whose properties about Brand can be referenced from   Book : Martindale    Page : 100   Edition : 37,

  ►   Brandname : Beta Nicip, Mesulid, Nicip, Nilide

  ►  Doseform : Gel with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 99   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, rectal, Topical,
Reference :-   Book : Martindale    Page : 99   Edition : 37,

  ►  Indication/uses : Acute pain, Osteoarthritis, Dysmenorrhea, Symptomatic treatment of sprains and tendinitis,
Reference :-   Book : Martindale    Page : 99   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nimesulide medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Acute pain, Osteoarthritis, Dysmenorrhea Oral 100 mg b.d.
2 Symptomatic treatment of sprains and tendinitis Topical 3 % Gel

Ref :-  Book : Martindale    Page : 99   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  

Ref :- Book :
►  Side Effect : Gastrointestinal disturbances, gastrointestinal discomfort, nausea, diarrhoea, headache, vertigo, Dizziness, Nervousness, tinnitus, Depression, drowsiness, insomnia, hypersensitivity reactions, fever, angioedema, bronchospasm, Rashes, anaemias, thrombocytopenia, neutropenia, eosinophilia, agranulocytosis, photosensitivity, Exacerbation of colitis, ,
Ref :-   Book : Martindale    Page : 99,100   Edition : 37,

►  Interaction : Azapropazone, Phenylbutazone, , Methotrexate, , , , Tacrolimus , , , , Phenytoin , , , , , Venlafaxine , Clopidogrel , Ticlopidine , Iloprost , Erlotinib, , , Pentoxifylline , Ritonavir, Mifepristone ,
Ref :-   Book : Martindale    Page : 99,103    Edition : 37,


►  Contraindication : Active peptic ulceration, severe heart failure, Moderate to severe heart failure, Ischaemic heart diseas, peripheral arterial disease, Cerebrovascular disease, hypertension, Left ventricular failure, Oedema, history of hypersensitivity reactions, It should also be used with caution in patients with asthma or allergic disorders,
Ref :-   Book : Martindale    Page : 99,102   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Interactions involving NSAIDs include enhancement of the effects of oral anticoagulants (especially by azapropazone and phenylbutazone) and increased plasma concentrations of lithium, methotrexate, and cardiac glycosides. The risk of nephrotoxicity may be increased if given with ACE inhibitors, ciclosporin, tacrolimus, or diuretics. There may also be an increased risk of hyperkalaemia with ACE inhibitors and some diuretics, including potassiumsparing diuretics. The antihypertensive effects of some antihypertensives including ACE inhibitors, beta blockers, and diuretics may be reduced. NSAIDs may increase the effects of phenytoin and sulfonylurea antidiabetics. The risk of gastrointestinal bleeding and ulceration associated with NSAIDs is increased when used with corticosteroids, the SSRIs, the SNRI venlafaxine, the antiplatelets clopidogrel and ticlopidine, iloprost, erlotinib, sibutramine, or, possibly, alcohol, bisphosphonates, or pentoxifylline. Ritonavir may increase the plasma concentrations of NSAIDs. Licensed product information for mifepristone advises of a theoretical risk that prostaglandin synthetase inhibition by NSAIDs or aspirin may alter the efficacy of mifepristone.,
Ref :-   Book : Martindale    Page : 99,103   Edition : 37,


  ►  Mechanism of Action :   Inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), decreasing the biosynthesis of downstream eicosanoids and thereby limiting the inflammatory response,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 761   Edition : 3,
 ►   

Dietary Products that produce same effect as  Nimesulide






►   Route of Elimination :   NA


►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA