Medicine :   
Nitrazepam is a Medicine belongs to Sedatives- hypnotics group whose properties about Brand can be referenced from   Book : Martindale    Page : 1117   Edition : 37,

  ►   Brandname : Alodorm, Mogadon, Dormalon, Dormo-Puren, Hypnotex, Nitavan, Remnos, Somnite

  ►  Doseform : Oral Suspension with   , Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1117   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1117   Edition : 37,

  ►  Indication/uses : insomnia, epilepsy, infantile spasms,
Reference :-   Book : Martindale    Page : 1117   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nitrazepam medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Insomnia Oral 5 mg Tablet Given at night, although 10 mg may be required in some patients. Elderly or debilitated patients should not be given more than half of the normal adult dose.

Ref :-  Book : Martindale    Page : 1117   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Epilepsy 1 Month 2 Year Oral 125 mcg/kg

Ref :- Book : Martindale    Page : 1117   Edition : 37,
►  Side Effect : drowsiness, Sedation, muscle weakness, ataxia, vertigo, headache, Confusion, Depression, slurred speech, dysarthria, changes in libido, tremor, visual disturbances, urinary retention, urinary incontinence, Gastrointestinal disturbances, changes in salivation, amnesia, paradoxical excitation, raised liver enzyme values, respiratory depression, hypotension, ,
Ref :-   Book : Martindale    Page : 1090,1116   Edition : 37,

►  Interaction : , , , , , , ,
Ref :-   Book : Martindale    Page : 1093,1116   Edition : 37,


►  Contraindication : hepatic impairment, Myasthenia gravis, pre-existing CNS depression or coma, respiratory depression, acute pulmonary insufficiency, renal impairment, sleep apnoea, chronic pulmonary insufficiency, Nitrazepam is not appropriate for the treatment of chronic psychosis or for phobic or obsessional states, Caution is required in patients with organic brain changes particularly arteriosclerosis,
Ref :-   Book : Martindale    Page : 1092,1116   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Enhanced sedation or respiratory and cardiovascular depression may occur if nitrazepam or other benzodiazepines are given with other drugs that have CNS depressant properties; these include alcohol, antidepressants, sedative antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, and opioid analgesics. The metabolism of most banzodiazipines is mediated primarily by the cytochrome P450 system, particularly the isoenzymes CYP2C19 and CYP3A4. Hence, adverse effects may also be produce by use with drugs that inhibit or induce or metabolized by these isoenzymes. Benzodiazepines such as nitrazepam that are metabolised primarily by hepatic microsomal oxidation may be more susceptible to pharmacokinetic changes than those eliminated primarily by glucuronide conjugation,
Ref :-   Book : Martindale    Page : 1093,1116   Edition : 37,


  ►  Mechanism of Action :   Weak allosteric agonists of the GABAA receptor that act to increase the frequency of receptor opening and potentiate effects of GABA.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 183   Edition : 3,
 ►   

Dietary Products that produce same effect as  Nitrazepam






►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal,
Ref :-   Book : Martindale    Page : 1116   Edition : 37,


►    Plasma Half-life :   Min value :-   24 hours,    Max value :-   30 hours,
Ref :-   Book : Martindale    Page : 1116   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   3 hours,
Ref :-   Book : Martindale    Page : 1116   Edition : 37,