Medicine :   
Nitrofurantoin is a Medicine belongs to Antibacterials group whose properties about Brand can be referenced from   Book : Martindale    Page : 335   Edition : 37, Martindale    Page : 333   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Martifur,Macrobid,Macrodantin,Ralodantin, Nifurantin, Nifuretten,Nitrobact

  ►  Doseform : Capsule with 25  mg, Capsule with 50  mg, Capsule with 100  mg, Suspension with 25  mg/5mL, Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 898   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 335   Edition : 37,

  ►  Indication/uses : Treatment of uncomplicated lower urinary-tract infections, including prophylaxis or long-term suppressive therapy in recurrent infection,
Reference :-   Book : Martindale    Page : 335   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nitrofurantoin medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Urinary-tract infections Oral 50 100 mg Capsule q.i.d. Dose: Given with food or milk. Treatment is usually continued for 7 days. A usual long-term prophylactic dose is 50 to 100 mg at bedtime.

Ref :-  Book : Martindale    Page : 335   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Urinary-tract infections 3 Month 12 Year Oral 3 mg/kg

Ref :- Book : Martindale    Page : 335   Edition : 37,
Precaution :- If a Patient is using 'Nitrofurantoin' drug in  Urinary infection   disease, then Please Contraindication: Pregnancy>38 weeks, decreased renal function .

Precaution :- If a Patient is using 'Nitrofurantoin' drug in  auto immune hemolytic anemia  disease, then Please Use with caution .

Precaution :- If a Patient is using 'Nitrofurantoin' drug in  thallasemia  disease, then Please Avoid .

►  Side Effect : nausea, vomiting, anorexia, abdominal pain, diarrhoea, headache, drowsiness, vertigo, Dizziness, nystagmus, benign intracranial hypertension, Irreversible peripheral neuropathy, hypersensitivity reactions, Skin rashes, Urticaria, pruritus, fever, sialadenitis, angioedema, anaphylaxis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, Pancreatitis, lupus-like syndrome, myalgia, arthralgia, Acute pulmonary sensitivity reactions, chills, eosinophilia, Cough, chest pain, dyspnoea, Pulmonary infiltration or consolidation, pleural effusion, Interstitial pneumonia, pulmonary fibrosis, megaloblastic anaemia, leucopenia, granulocytopenia, agranulocytosis, thrombocytopenia, aplastic anaemia, haemolytic anaemia, Transient alopecia, Brownish discoloration of the urine, ,
Ref :-   Book : Martindale    Page : 334-335   Edition : 37,

►  Interaction : , Probenecid , Sulfinpyrazone, ,
Ref :-   Book : Martindale    Page : 335   Edition : 37,


►  Contraindication : Hypersensitivity, renal impairment, G6PD deficiency, Infants,
Ref :-   Book : Martindale    Page : 335   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  The antibacterial activity of nitrofurantoin may be decreased in the presence of carbonic anhydrase inhibitors and other drugs that alkalinise the urine. Probenecid or sulfinpyrazone should not be given with nitrofurantoin as they may reduce its excretion. Magnesium trisilicate may reduce the absorption of nitrofurantoin but it is not clear whether this applies to other antacids.,
Ref :-   Book : Martindale    Page : 335   Edition : 37,


  ►  Mechanism of Action :   Nitrofurantoin has a complex mechanism of action that is not fully understood. Antibacterial activity appears to correlate with rapid intracellular conversion of nitrofurantoin to highly reactive intermediates by bacterial reductases. These intermediates react nonspecifically with many ribosomal proteins and disrupt the synthesis of proteins, RNA, DNA, and metabolic processes. It is not known which of the multiple actions of nitrofurantoin is primarily responsible for its bactericidal activity. ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 892   Edition : 12,
 ►   

Dietary Products that produce same effect as  Nitrofurantoin

  •    Eucalyptus oil ,    Red algae, have compounds that have the same effect as Nitrofurantoin through an alternate pathway



 ►    Nitrofurantoin can cause a  'Vitamin K'  deficiency.
 ►    'Vitamin C'  should be taken regularly when taking  Nitrofurantoin
 ►   
►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 335   Edition : 37,


►    Plasma Half-life :   Min value :-   0.3 hours,    Max value :-   1 hours,
Ref :-   Book : Martindale    Page : 335   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA