Medicine :   
Nitroglycerine (glyceryl trinitrate) is a Medicine belongs to group whose properties about Brand can be referenced from   Book : Martindale    Page : 1429   Edition : 37,

  ►   Brandname : Nitro-bid,Nitrostat,Nitroderm,Nitrocontin

  ►  Doseform : Tablet with 0.3  mg, Tablet with 0.4  mg, Tablet with 0.6  mg, Aerosol with 0.4  mg, Capsule with 2.5  mg, Capsule with 6.5  mg, Capsule with 9  mg, Injection with 5  mg/ml, Ointment with 20  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 209   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : sublingual, buccal, Oral, Transdermal, IV,
Reference :-   Book : Martindale    Page : 1427   Edition : 37,

  ►  Indication/uses : NA
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nitroglycerine (glyceryl trinitrate) medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Acute angina sublingual 300 600 micrograms Tablet
2 Acute angina inhalation 400 micrograms Aerosol
3 Stable angina pectoris Oral 2.5 6.5 mg Capsule t.i.d/q.i.d
4 Stable angina pectoris Transdermal 2 % Ointment b.d.
5 Stable angina pectoris Transdermal 2 % Ointment q.i.d.
6 Stable angina pectoris buccal 2 5 mg Tablet t.i.d.
7 unstable angina IV infusion 5 10 micrograms/minute Injection
8 unstable angina sublingual upto 5 mg Tablet

Ref :-  Book : Martindale    Page : 1427- 1428   Edition : 37, Martindale    Page : 1427-1428   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Acute angina sublingual 300 600 micrograms Tablet
2 >1 Day > 28 Month IV infusion 200 500 nanograms/kg per minute Injection
3 IV infusion 200 500 nanograms/kg per minute Injection

Ref :- Book : Martindale    Page : 1427, 1428   Edition : 37, Martindale    Page : 1428   Edition : 37,
Precaution :- If a Patient is using 'Nitroglycerine (glyceryl trinitrate)' drug in  HYPERTROPHIC CARDIOMYOPATHY  disease, then Please be used with caution .

Precaution :- If a Patient is using 'Nitroglycerine (glyceryl trinitrate)' drug in stable angina pectoris disease, then Please use with caution   if he ever suffered from methemoglobinemia disease.
►  Side Effect : flushing of the face, Dizziness, tachycardia, vomiting, Restlessness, Blurred Vision, syncope, cyanosis, methaemoglobinaemia, impairment of respiration, bradycardia, Contact dermatitis, local irritation, erythema, asystole, throbbing headache,
Ref :-   Book : Martindale    Page : 1427   Edition : 37,

►  Interaction : Heparin , Atropine , Ergotamine, Alteplase ,
Ref :-   Book : Martindale    Page : 1427   Edition : 37,


►  Contraindication : NA
  ►    Mechanism of Drug Drug Interaction :  The hypotensive effects of glyceryl trinitrate may be enhanced by alcohol, and by vasodilators and other drugs with hypotensive actions. The effectiveness of sublingual and buccal tablet preparations may be reduced by drugs that cause dry mouth since dissolution may be delayed.,
Ref :-   Book : Martindale    Page : 1427   Edition : 37,


  ►  Mechanism of Action :   Nitrate and nitroprusside: Donate NO, which activates guanylyl cyclase and decreases dephosphorylation of myosin light chain in vascular smooth muscle, causing vasodilation .inhaled nitric oxide gas: selectively dilate the pulmonary vasculature. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 368   Edition : 3,
 ►   

Dietary Products that produce same effect as  Nitroglycerine (glyceryl trinitrate)

  •    Cynanchum wilfordii, compounds that act on the same pathway as Nitroglycerine (glyceryl trinitrate)





►   Route of Elimination :   NA


►    Plasma Half-life :   Min value :-   0.01 hours,    Max value :-   0.05 hours,
Ref :-   Book : Goodman    Page : 751   Edition : 12 ,


►    Peak Plasma Concentration :   Min value :-   0.06 hours,    Max value :-   ,
Ref :-   Book : Goodman    Page : 751   Edition : 12,