Medicine :   
Nizatidine is a Medicine belongs to H2 histamine receptor blockers group whose properties about Brand can be referenced from   Book : Martindale    Page : 1905   Edition : 37,

  ►   Brandname : Nizac, Tacidine, Tazac, Axid

  ►  Doseform : Tablet with 75  mg, Capsule with 150  mg, Capsule with 300  mg, Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12, Martindale    Page : 1905   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion,
Reference :-   Book : Martindale    Page : 1905   Edition : 37,

  ►  Indication/uses : Bening gastric and duodenal ulceration, and NSAID-associated ulceration, gastro-oesophageal reflux disease, dyspepsia,
Reference :-   Book : Martindale    Page : 1905   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nizatidine medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Bening gastric and duodenal ulceration, and NSAID-associated ulceration Oral 300 mg Capsule Given: either as a single dose at bedtime or in 2 divided doses, for 4 to 8 weeks. Where appropriate a maintenance dose of 150 mg daily may be given at night.
2 Gastro-oesophageal reflux disease Oral 150 300 mg Capsule b.d. Dose: recommended for up to 12 weeks.
3 Short-term symptomatic relief of dyspepsia Oral 75 mg Tablet Dose: Repeated if necessary, up to a maximum of 150 mg daily may be taken by mouth for up to 14 days.
4 Short-term symptomatic relief of dyspepsia Nizatidine may be given intravenously by continuous or intermittent infusion. For continuous infusion, 300 mg is diluted in 150 mL of a compatible infusion fluid and given at a rate of 10 mg/hour. For intermittent infusion, 100 mg may be diluted in 50 mL of infusion fluid and given over 15 minutes, three times daiy. The total intravenous dose should not exceed 480 mg daily. Ref Martindale pg no 1905 ed 37.

Ref :-  Book : Martindale    Page : 1905   Edition : 37,    Page :    Edition : ,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Oesophagitis and gastro-oesophageal reflux disease 12 Year Oral 150 mg Capsule

Ref :- Book : Martindale    Page : 1905   Edition : 37,
►  Side Effect : headache, Dizziness, arthralgia, myalgia, constipation, diarrhea, necrotising enterocolitis, Pancreatitis,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 818   Edition : 3,

►  Interaction : Dasatinib, Ketoconazole , Itraconazole , Posaconazole , Phenytoin , Theophylline , Lidocaine , ,
Ref :-   Book : Martindale    Page : 1868,1905   Edition : 37,


►  Contraindication : Gastric malignancies,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 1830   Edition : 38,
  ►    Mechanism of Drug Drug Interaction :  Nizatidine does not inhibit cytochrome P450, and therefore is considered to have little effect on the metabolism of other drugs. However, like other H2-antagonists its effects on gastric pH may affect the absorption of some drugs whose absorption is dependent on an acid gastric pH. It can reduce the absorption of drugs such as dasatinib, ketoconazole, and possibly itraconazole, whose absorption is dependent on an acid gastric pH. Nizatidine may inhibit the hepatic metabolism of many drugs by binding to cytochrome P450 isoenzymes, notably CYP1A2, CYP2C9, CYP2D6, and CYP3A4. Although many such interactions may occur, only a few are considered clinically significant, notably those with phenytoin, theophylline, lidocaine, and oral anticoagulants. Avoidance of the combination, or a reduction in the dosage of these drugs may be required.,
Ref :-   Book : Martindale    Page : 1868,1905   Edition : 37,


  ►  Mechanism of Action :   The H2 receptor antagonists inhibit acid production by reversibly competing with histamine for binding to H2 receptors on the basolateral membrane of parietal cells.,
Ref :-   Book : Goodman    Page : 1313   Edition : 12,
 ►   

Dietary Products that produce same effect as  Nizatidine




 ►    Nizatidine can cause a  'Folic acid '  deficiency. Nizatidine can cause a  'Iron'  deficiency. Nizatidine can cause a  'Vitamin B12'  deficiency.
 ►    'Magnesium'  should be taken regularly when taking  Nizatidine
 ►   
►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal,
Ref :-   Book : Martindale    Page : 1905   Edition : 37,


►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   2 hours,
Ref :-   Book : Martindale    Page : 1905   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   3 hours,
Ref :-   Book : Martindale    Page : 1905   Edition : 37,