Medicine :   
Noradrenaline/Norepinephrine is a Medicine belongs to Sympathomimetic Drugs group whose properties about Brand can be referenced from   Book : Martindale    Page : 1494   Edition : 37,

  ►   Brandname : Adrenor,Levophed,Arterenol

  ►  Doseform : Injection with 1  mg/ml, Local solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 148   Edition : 12, Martindale    Page : 1494   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion, Local,
Reference :-   Book : Martindale    Page : 1494   Edition : 37,

  ►  Indication/uses : Acute hypotensive states, Cardiac arrest, Noradrenaline used in local anaesthesia to diminish the absorption and localise the effect of the local anaesthetic, Locally applied solutions have been used to control bleeding in upper gastrointestinal haemorrhage and similar disorders,
Reference :-   Book : Martindale    Page : 1494   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Noradrenaline/Norepinephrine medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Acute hypotensive states IV infusion 10 µg/minute Injection Ref; Martindale pg no 1494 ed 37

Ref :-  Book : Goodman    Page : 287   Edition : 12,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Acute hypotension IV infusion 20 100 nanograms/kg per minute Injection

Ref :- Book : Martindale    Page : 1494   Edition : 37,
►  Side Effect : anxiety, fear, Restlessness, insomnia, Confusion, irritability, headache, psychotic states, dyspnoea, weakness, anorexia, nausea, vomiting, palpitations, tachycardia, arrhythmia, angina, cardiac arrest, hypotension, Dizziness, flushing, fainting, Tissue necrosis, gangrene of the extremities, severe phlebitis, local pain, local irritation, mydriasis, difficulty in micturition, urinary retention, piloerection, sweating, increased salivation, hypokalaemia, Muscle tremor,
Ref :-   Book : Martindale    Page : 1493,1544   Edition : 37,

►  Interaction : Cyclopentolate , , Halothane , Guanethidine, dexamfetamine, Dopexamine, Ephedrine , Isometheptene, Mephentermine, Methylphenidate , Phentermine, Phenylephrine , Phenylpropanolamine, Pseudoephedrine, , , , ,
Ref :-   Book : Martindale    Page : 1494,1545   Edition : 37,


►  Contraindication : Peripheral vascular thrombosis, profound hypoxia, hypercapnia, hypotension from loss of blood volume,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 435   Edition : 3,
  ►    Mechanism of Drug Drug Interaction :  Increased cardiac effects may occur with drugs that increase the sensitivity of the myocardium to beta1 agonists; hazardous arrhythmias may occur with volatile anaesthetics, particularly cyclopropane or halothane. Direct-acting sympathomimetics with alpha agonist actions specifically reverse the hypotensive effect of adrenergic neurone blockers such as guanethidine, and severe hypertension may result. Sympathomimetics for which the risk is particularly high include dexamfetamine, dopamine, dopexamine, ephedrine, isometheptene, mephentermine, metaraminol, methylphenidate, phentermine, phenylephrine, phenylpropanolamine, and pseudoephedrine. Tricyclic antidepressants block the inactivation of adrenaline and noradrenaline by uptake into the nerve endings and may increase their effect; hypertension and arrhythmias may occur. Severe hypertension may occur if noradrenaline is given to patients taking tricyclic antidepressants since tricyclics block the uptake of noradrenaline into nerve endings. ,
Ref :-   Book : Martindale    Page : 1494,1545   Edition : 37,


  ►  Mechanism of Action :   Increase cAMP by activating G protein-coupled adrenergic receptors; acting at cardiac beta-1 adrenergic receptors, agonist have positive inotropic, chronotropic and lusitropic effects.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 435   Edition : 12,
 ►   

Dietary Products that produce same effect as  Noradrenaline/Norepinephrine



 ►    Dietary Products that enhance the activity of Noradrenaline/Norepinephrine
  • Piperine



►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1494   Edition : 37,


►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA