Medicine :   
Norfloxacin is a Medicine belongs to FLUOROQUINOLONES group whose properties about Brand can be referenced from   Book : Martindale    Page : 336-337   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Insensye, Norflohexal, Noroxin, Bactracid, Barazan, Chibroxin, Bacigyl, Bacigyl-N, Biofloxin, Utinor, Noroxin,Norflox

  ►  Doseform : Tablet with 400  mg, Eye Drop with   , Ophthalmic Solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 838   Edition : 12, Martindale    Page : 336   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, ophthalmic,
Reference :-   Book : Martindale    Page : 336   Edition : 37,

  ►  Indication/uses : urinary-tract infections, chronic bacterial prostatitis, Uncomplicated gonorrhoea, eye infections, Complicated pyelonephritis,
Reference :-   Book : Martindale    Page : 336   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Norfloxacin medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Urinary-tract infections Oral 400 mg Tablet b.d. Norfloxacin is given orally at least 1 hour before, or 2 hours after, food or milk. Dose given for 3 to 10 days. Treatment may need to be continued for up to 12 weeks in chronic relapsing urinary- tract infections; it may be possible to reduce the dose to 400 mg once daily if there is an adequate response within the first 4 weeks.
2 Chronic bacterial prostatitis Oral 400 mg Tablet b.d. Norfloxacin is given orally at least 1 hour before, or 2 hours after, food or milk. It is a 28-day course
3 Uncomplicated gonorrhoea Oral 800 mg Tablet Norfloxacin is given orally at least 1 hour before, or 2 hours after, food or milk. Given as single dose.
4 Eye infections ophthalmic 0.3 % Eye Drop

Ref :-  Book : Martindale    Page : 336   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  

Ref :- Book :
►  Side Effect : intestinal functional disturbances, nausea, vomiting, diarrhoea, abdominal pain, dyspepsia, headache, Dizziness, Confusion, insomnia, Restlessness, tremor, drowsiness, nightmares, hallucinations, psychotic reactions, Depression, Convulsions, intracranial hypertension, paraesthesia, peripheral neuropathy, rash, pruritus, photosensitivity, anaphylaxis, tendon damage, Crystalluria, transient increases in serum creatinine or blood urea nitrogen, Elevated liver enzyme values, jaundice, hepatitis, eosinophilia, leucopenia, thrombocytopenia, tachycardia, hypotension, oedema, syncope, hot flushes, sweating, Pain and irritation at the site of infusion, Local burning or discomfort, keratopathy, corneal staining, corneal precipitates or infiltrates, photophobia, ,
Ref :-   Book : Martindale    Page : 265,336   Edition : 37,

►  Interaction : Tizanidine , Warfarin , Glibenclamide , Methotrexate, Probenecid , , , , , Quinidine , Procainamide , , Amiodarone , Sotalol , , Astemizole, Terfenadine, Cisapride , Erythromycin , Pentamidine , , ,
Ref :-   Book : Martindale    Page : 267,336   Edition : 37,


►  Contraindication : Caution in patients with epilepsy or a history of CNS disorders, Care is also necessary in those with renal impairment, G6PD deficiency, or myasthenia gravis, Patients aged under 18 years, Tendon pain, inflammation, or rupture, The ability to drive or operate machinery may be impaired, especially when alcohol is also taken., It should be avoided or used with caution in patients with QT prolongation or relevant risk factors such as uncorrected electrolyte disturbances, bradycardia, or pre-existing cardiac disease. Certain drugs may also increase the risk.,
Ref :-   Book : Martindale    Page : 236,266   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Fluoroquinolones, including norfloxacin, are known to inhibit the cytochrome P450 isoenzyme CYP1A2 and may increase plasma concentrations of drugs, such as theophylline and tizanidine, that are metabolised by this isoenzyme. Use of norfloxacin with tizanidine is contra-indicated. norfloxacin is reported to enhance the effect of oral anticoagulants such as warfarin and the oral antidiabetic glibenclamide. Severe hypoglycaemia, sometimes fatal, has occurred in patients also taking glibenclamide. Renal tubular secretion of methotrexate may be inhibited by norfloxacin, potentially increasing its toxicity. The excretion of norfloxacin or related drugs is reduced and plasma concentrations may be increased by probenecid. Cations such as aluminium, calcium, magnesium, or iron reduce the absorption of oral norfloxacin or related drugs when given together. Changes in the pharmacokinetics of fluoroquinolones have been reported when given with histamine H2 antagonists, possibly due to changes in gastric pH, but do not seem to be of much clinical significance. Transient increases in serum creatinine have occurred when norfloxacin is given with ciclosporin; monitoring of serum creatinine concentrations is recommended. Altered serum concentrations of phenytoin have been reported in patients also receiving norfloxacin. Some fluoroquinolones have the potential to prolong the QT interval and should be avoided in patients also receiving class Ia antiarrhythmic drugs (such as quinidine and procainamide) or class III antiarrhythmics (such as amiodarone and sotalol). In addition, caution should be exercised when they are used with other drugs known to have this effect (such as the antihistamines astemizole and terfenadine, cisapride, erythromycin, pentamidine, phenothiazines, or tricyclic antidepressants).,
Ref :-   Book : Martindale    Page : 267,336   Edition : 37,


  ►  Mechanism of Action :   The quinolone antibiotics target bacterial DNA gyrase and topoisomerase IV. For many gram-positive bacteria (such as S. aureus), topoisomerase IV is the primary activity inhibited by the quinolones.,
Ref :-   Book : Goodman    Page : 1470   Edition : 12,
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Dietary Products that produce same effect as  Norfloxacin




 ►    Norfloxacin can cause a  'Vitamin K'  deficiency. Norfloxacin can cause a  'Calcium'  deficiency. Norfloxacin can cause a  'Magnesium'  deficiency.
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 ►   
►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal,
Ref :-   Book : Martindale    Page : 336   Edition : 37,


►    Plasma Half-life :   Min value :-   3 hours,    Max value :-   4 hours,
Ref :-   Book : Martindale    Page : 336   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
Ref :-   Book : Martindale    Page : 336   Edition : 37,