Medicine :   
Nadolol is a Medicine belongs to group whose properties about Brand can be referenced from   Book : Martindale    Page : 1478   Edition : 37,

  ►   Brandname : Corgard

  ►  Doseform : with 20  , with 40  , with 80  , with 120  , with 160  ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 166   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1478   Edition : 37,

  ►  Indication/uses : hypertension, angina pectoris, cardiac arrhythmias, Prophylaxis of migraine, As an adjunct in the treatment of hyperthyroidism,
Reference :-   Book : Martindale    Page : 1478   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► Nadolol medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 hypertension Oral 40 80 mg Tablet Dose increased weekly according to response to 240 mg or more daily.
2 Angina pectoris Oral 40 mg Tablet Dose increased weekly according to response to usual doses of up to 160 mg daily; some patients may require up to 240 mg daily.
3 Cardiac arrhythmias Oral 40 160 mg Tablet o.d.
4 Prophylaxis of migraine Oral 40 160 mg Tablet o.d.
5 As an adjunct in the treatment of hyperthyroidism Oral 80 160 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 1478   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1

Ref :- Book :    Page :    Edition : ,
►  Side Effect : heart failure, heart block, bronchospasm, fatigue, coldness of the extremities, bradycardia, hypotension, shortness of breath, dyspnoea, pneumonitis, pulmonary fibrosis, pleurisy, headache, Depression, Dizziness, hallucinations, Confusion, amnesia, Sleep disturbances, nightmares, coma, Convulsions, paresthesia, arthralgia, myopathies, muscle cramps, Raynaud’s syndrome, nausea, vomiting, diarrhoea, constipation, abdominal cramping, Hypoglycaemia, Hyperglycaemia, changes in blood concentrations of triglycerides and cholesterol, Rashes, pruritus, exacerbation of psoriasis, excess sweating, reversible alopecia, Blurred Vision, conjunctivitis, soreness, nonthrombocytopenic purpura, thrombocytopenia, transient eosinophilia, Systemic lupus erythematous (SLE), dry mouth, raised liver enzymes, male impotence, sclerosing peritonitis, retroperitoneal fibrosis, ,
Ref :-   Book : Martindale    Page : 1349,1478   Edition : 37,

►  Interaction : , , Clonidine , Interleukin 2/Aldesleukin, , , , Verapamil , , Epinephrine (adrenaline) , Insulin , , , Cholestyramine , , Rifampicin , Cimetidine , Erythromycin , Fluvoxamine, Hydralazine , Labetalol , Propranolol , Timolol , Atenolol ,
Ref :-   Book : Martindale    Page : 1352,1478   Edition : 37,


►  Contraindication : Bronchospasm, asthma, metabolic acidosis, cardiogenic shock, hypotension, severe peripheral arterial disease, Sinus bradycardia, second or third degree AV block, prinzmetal angina, severity of anaphylactoid reactions, Pregnancy, Phaeochromocytoma should not be given beta blockers without alpha-adrenoceptor blocking therapy as well,
Ref :-   Book : Martindale    Page : 1351,1478   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Drugs that enhance the antihypertensive effects of beta blockers, such as ACE inhibitors, calcium-channel blockers, and clonidine may be useful in controlling hypertension. Drugs that cause hypotension such as aldesleukin and general anaesthetics also enhance the antihypertensive effects of beta blockers while other drugs, for example NSAIDs, antagonise the antihypertensive effects. Use of beta blockers with other cardiac depressants such as antiarrhythmics and rate-limiting calciumchannel blockers can precipitate bradycardia and heart block; the combination of intravenous verapamil and beta blockers should especially be avoided. Patients taking beta blockers may have an exaggerated hypertensive response to adrenaline, caused by unopposed alpha-mediated vasoconstriction, while the bronchodilator effects are inhibited; the response to adrenaline given for anaphylaxis may also be reduced in patients on long-term treatment with beta blockers. In diabetic patients beta blockers can reduce the response to insulin and oral hypoglycaemics through their effects on pancreatic beta receptors. Drugs that reduce absorption include aluminium salts and bile-acid binding resins such as colestyramine. Metabolism of some beta blockers can be increased by drugs such as barbiturates and rifampicin and decreased with drugs such as cimetidine, erythromycin, fluvoxamine, and hydralazine. Drugs that alter hepatic blood flow also affect metabolism of some beta blockers. For example, cimetidine and hydralazine decrease hepatic blood flow and this contributes to the decreased hepatic clearance seen with these drugs. Drugs that influence hepatic metabolism affect beta blockers that are extensively metabolised, such as labetalol, propranolol, and timolol, while beta blockers that are excreted largely unchanged, for example atenolol and nadolol, are unaffected. ,
Ref :-   Book : Martindale    Page : 1352,1478   Edition : 37,


  ►  Mechanism of Action :   Nadolol is a non-cardioselective beta blocker. It is reported to lack intrinsic sympathomimetic and membrane-stabilising activity.,
Ref :-   Book : Martindale    Page : 1478   Edition : 37,
 ►   

Dietary Products that produce same effect as  Nadolol






►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1478   Edition : 37,


►    Plasma Half-life :   Min value :-   12 hours,    Max value :-   24 hours,
Ref :-   Book : Martindale    Page : 1478   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   4 hours,
Ref :-   Book : Martindale    Page : 1478   Edition : 37,