Medicine :   
Nimodipine is a Medicine belongs to Cardiovascular drugs group whose properties about Brand can be referenced from   Book : Martindale    Page : 1490   Edition : 37,

  ►   Brandname : Nimotop

  ►  Doseform : Injection with   , Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1491   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 1491   Edition : 37,

  ►  Indication/uses : cerebrovascular disorders, Prevention and treatment of ischaemic neurological deficits after aneurysmal subarachnoid haemorrhage,
Reference :-   Book : Martindale    Page : 1490   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓

► Nimodipine medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Reduce the incidence and severity of neurological deficit after aneurysmal haemorrhage Oral 60 mg Tablet Dose: Given every 4 hours.
2 IV infusion 1 mg/hour Injection If cerebral ischaemia occurs or has already occurred, neurological deficit may be treated by intravenous infusion of nimodipine. It should be given via a bypass into a running intravenous infusion into a central vein. The initial dose should be nimodipine 1 mg/hour for 2 hours, increased (provided that no severe decrease in blood pressure occurs) to 2 mg/hour. The starting dose should be reduced to 500 micrograms/hour, or even lower if necessary, in patients weighing less than 70 kg and in those with unstable blood pressure; a similar reduction in dosage has been suggested in hepatic impairment, and blood pressure should be closely monitored. Treatment should be started as soon as possible and continued for at least 5 and no more than 14 days; if the patient has already received oral nimodipine, the total duration of nimodipine use should not exceed 21 days.

Ref :-  Book : Martindale    Page : 1490   Edition : 37,

For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  

Ref :- Book :    Page :    Edition : ,
►  Side Effect : Dizziness, flushing, headache, hypotension, peripheral oedema, tachycardia, palpitations, nausea, constipation, Gastrointestinal disturbances, increased micturition frequency, lethargy, eye pain, visual disturbances, syncope, vertigo, migraine, mood disturbances, Rashes, erythema multiforme, fever, abnormalities in liver function, hypersensitivity reactions, gingival hyperplasia, pruritus, myalgia, tremor, Gynaecomastia, impotence, gastrointestinal obstruction,
Ref :-   Book : Martindale    Page : 1482, 1490   Edition : 37, Martindale    Page : 1482, 1490   Edition : ,

►  Interaction : , Interleukin 2/Aldesleukin, , Quinidine , Carbamazapine , Phenytoin , Rifampicin , Cimetidine , Erythromycin , ,
Ref :-   Book : Martindale    Page : 1485,1490   Edition : 37,

►  Contraindication : Nimodipine should be used with caution in patients with cerebral oedema or severely raised intracranial pressure, It should be used with caution in patients with hypotension, in patients whose cardiac reserve is poor, and in those with heart failure since deterioration of heart failure has been noted., It should not be used in cardiogenic shock, in patients who have suffered a myocardial infarction in the previous 2 to 4 weeks, or in acute unstable angina., It should not be used to treat an anginal attack in chronic stable angina, nor should it be used for the acute reduction of blood pressure in adults, though it may be used for this purpose in children, In patients with severe aortic stenosis nifedipine may increase the risk of developing heart failure.,
Ref :-   Book : Martindale    Page : 1485,1490   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Nimodipine may enhance the antihypertensive effects of other antihypertensive drugs such as beta blockers although the combination is generally well tolerated. Enhanced antihypertensive effects may also be seen if used with drugs such as aldesleukin and antipsychotics that cause hypotension. Nimodipine may modify insulin and glucose responsese and therefore diabetic patients may need to adjust their antidiabetic treatment when receiving nifedipine. Nimodipine is extensively metabolised in the liver by the cytochrome P450 isoenzyme CYP3A4, and interactions may occur with other drugs, such as quinidine, sharing the same metabolic pathway, and with enzyme inducers, such as carbamazepine, phenytoin, and rifampicin, and enzyme inhibitors, such as cimetidine, erythromycin, and HIVprotease inhibitors.,
Ref :-   Book : Martindale    Page : 1485,1490   Edition : 37,

  ►  Mechanism of Action :   Nimodipine is a dihydropyridine calcium-channel blocker. It is a peripheral and coronary vasodilator, but, unlike the rate-limiting calcium-channel blockers verapamil or diltiazem, has little or no effect on cardiac conduction and negative inotropic activity is rarely seen at therapeutic doses. Use of nimodipine results primarily in vasodilatation, with reduced peripheral resistance, blood pressure, and afterload, increased coronary blood flow, and a reflex increase in heart rate. This in turn results in an increase in myocardial oxygen supply and cardiac output.,
Ref :-   Book : Martindale    Page : 1487,1490   Edition : 37,

Dietary Products that produce same effect as  Nimodipine

  •    Olive oil,    Ginger (Zingiber officinale), compounds that act on the same pathway as Nimodipine
  •    Olive oil, have compounds that have the same effect as Nimodipine through an alternate pathway

 ►    Dietary Products that enhance the activity of Nimodipine
  • Vitamin C
  • Glucosides
  • Fat
  • Nondigestible Fiber
  • Epigallocatechin gallate
  • Apple pectin

►   Route of Elimination :   Hepatic (Metabolism), Renal, Biliary, Faecal,
Ref :-   Book : Martindale    Page : 1490   Edition : 37,

►    Plasma Half-life :   Min value :-   9 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1490   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1490   Edition : 37,