Medicine :   
Norethisterone is a Medicine belongs to Progestins group whose properties about Brand can be referenced from   Book : Martindale    Page : 2328   Edition : 37,

  ►   Brandname : Cycloreg,Noristerat,Micronor,Aygestin

  ►  Doseform : Tablet with 5  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 2327   Edition : 37,

  ►  Indication/uses : hormonal contraceptive, Menopausal HRT., menorrhagia, endocarditis, breast cancer, premenstrual syndrome, establish a menstrual cycle, Maintain sexual maturation,
Reference :-   Book : Martindale    Page : 2327, 2328   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓

► Norethisterone medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 hormonal contraceptive Oral 350 micrograms Tablet Dose: Given daily
2 hormonal contraceptive Oral 0.5 1 mg Tablet Dose: given with an oestrogen.
3 Menopausal HRT Oral 700 micrograms Tablet Dose: Given daily
4 Menorrhagia Oral 10 15 mg Tablet Dose: Given daily
5 Endometriosis Oral 10 25 mg Tablet Dose: Given daily
6 Premenstrual syndrome Oral Upto 15 mg Tablet Dose: Given daily.
7 Breast cancer Oral Upto 60 mg Tablet Dose: Given daily.

Ref :-  Book : Martindale    Page : 2327-2328   Edition : 37,

For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Establish a menstrual cycle Oral 5 mg Tablet
2 Maintain sexual maturation Oral 5 mg Tablet

Ref :- Book : Martindale    Page : 2328   Edition : 37,
►  Side Effect : Gastrointestinal disturbances, Changes in appetite or weight, fluid retention, oedema, acne, Chloasma, chloasma (melasma), allergic skin rashes, Urticaria, mental depression, Gynaecomastia, changes in libido, hair loss, Hirsutism, fatigue, drowsiness, insomnia, fever, headache, premenstrual syndrome-like symptoms, altered menstrual cycles, irregular menstrual bleeding, Alterations in serum lipid profile , Pain, diarrhoea, Flatulence, breast tenderness, spotting, Breakthrough bleeding, ,
Ref :-   Book : Martindale    Page : 2327,2333,2263   Edition : 37,

►  Interaction : Carbamazapine , Griseofulvin , Phenobarbital , Phenytoin , Rifampicin , ,
Ref :-   Book : Martindale    Page : 2271,2327,2333   Edition : 37,

►  Contraindication : hypertension, cardiac impairment, renal impairment, asthma, Epilepsy, migraine, other conditions which may be aggravated by fluid retention, Undiagnosed vaginal bleeding, history or current high risk of arterial disease, hepatic impairment, Breast or genital- tract carcinoma,
Ref :-   Book : Martindale    Page : 2327,2333   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Enzyme-inducing drugs such as carbamazepine, griseofulvin, phenobarbital, phenytoin, and rifampicin may enhance the clearance of norethisterone. These interactions are likely to reduce the efficacy of norethisterone -only contraceptives, and additional or alternative contraceptive measures are recommended. Aminoglutethimide markedly reduces the plasma concentrations of norethisterone possibly through a hepatic enzyme-inducing effect; an increase in norethisterone dose is likely to be required. Since norethisterone can influence diabetic control an adjustment in antidiabetic dosage could be required. Norethisterone may inhibit ciclosporin metabolism leading to increased plasma ciclosporin concentrations and a risk of toxicity. Enzyme-inducing drugs can cause combined oral contraceptives to fail by increasing their metabolism and clearance. This effect is well established for a number of antiepileptics, griseofulvin, and rifamycin antibacterials, and has also been suggested for some antivirals and for modafinil. Although less well documented, these interactions would also be expected to apply to progestogen-only contraceptives.,
Ref :-   Book : Martindale    Page : 2271,2327,2333   Edition : 37,

  ►  Mechanism of Action :   After frequency of GnRH pulsing and decrease anterior pituitary gland responsiveness to GnRH. Secondary mechanisms of pregnancy prevention include alterations in tubal peristalsis, endometrial receptivity, and cervical mucus secretions, which together prevent the proper transport of both egg and sperm.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 523   Edition : 3,

Dietary Products that produce same effect as  Norethisterone

►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal,
Ref :-   Book : Martindale    Page : 2327   Edition : 37,

►    Plasma Half-life :   Min value :-   8 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 2327   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
Ref :-   Book : Martindale    Page : 2327   Edition : ,