Medicine :   
Norgestrel/Levonorgestrel is a Medicine belongs to sex hormone group whose properties about Brand can be referenced from   Book : Martindale    Page : 2330   Edition : 37,

  ►   Brandname : Ecee,Norlevo,Levonelle,Mirena,Norgeston,Ovrette,Microlut, 28 mini, Duofem, Levogynon

  ►  Doseform : Capsule with   , Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12, Martindale    Page : 2330   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Transdermal,
Reference :-   Book : Martindale    Page : 2329   Edition : 37,

  ►  Indication/uses : hormonal contraceptive, menorrhagia, emergency Contraception, menopausal HRT,
Reference :-   Book : Martindale    Page : 2329   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓

► Norgestrel/Levonorgestrel medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 hormonal contraceptive Oral 30 micrograms Tablet
2 hormonal contraceptive Oral 150 micrograms Tablet Dose: As monophasic combined oral contraceptives: (doses may range from a low dose of 100 micrograms of levonorgestrel in some preparations up to 250 micrograms in others; a preparation containing 90 micrograms of levonorgestrel for continuous use without a tabletfree interval is also available)
3 hormonal contraceptive Oral 50 125 micrograms Tablet Dose: In triphasic preparations.
4 Emergency Contraception Oral 1.5 mg Tablet Dose: Given within 72 hours of coitus (preferably as soon as possible). Alternatively, a dose of 750 micrograms is given within 72 hours of coitus (preferably as soon as possible), and repeated after 12 hours. Another regimen uses levonorgestrel 500 micrograms plus ethinylestradiol 100 micrograms, given within 72 hours of coitus and repeated after 12 hours
5 Menopausal HRT Oral 75 250 micrograms Tablet Dose: Given 10 to 12 days of a 28-day cycle.
6 Menopausal HRT Transdermal 10 micrograms Transdermal Patch Dose: Per 24 hours, which is applied once weekly for 2 weeks of a 4-week cycle. Alternatively, a patch releasing 7 or 15 micrograms per 24 hours with an oestrogen is applied once weekly for continuous HRT
7 An intra-uterine device is available for contraception or menorrhagia, containing a total of 52 mg of levonorgestrel which is released at an initial rate of 20 micrograms per 24 hours. The device is effective for 5 years.

Ref :-  Book : Martindale    Page : 2329   Edition : 37,

For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  

Ref :- Book :    Page :    Edition : ,
►  Side Effect : gastrointestinal disturbance, Change in appetite or weight, fluid retention, oedema, acne, chloasma (melasma), allergic skin rashes, Urticaria, mental depression, Gynaecomastia, changes in libido, hair loss, Hirsutism, fatigue, drowsiness, insomnia, fever, headache, premenstrual syndrome-like symptoms, altered menstrual cycles, irregular menstrual bleeding, Alterations in serum lipid profile , amenorrhoea, Pain, diarrhoea, Flatulence, , breast tenderness, spotting, Breakthrough bleeding,
Ref :-   Book : Martindale    Page : 2263,2329,2333   Edition : 37, Martindale    Page : 2263,2329,2333   Edition : 37,

►  Interaction : Carbamazapine , Griseofulvin , Phenobarbital , Phenytoin , Rifampicin , ,
Ref :-   Book : Martindale    Page : 2271,2329,2333   Edition : 37,

►  Contraindication : It should be used with caution in patients with hypertension, cardiac or renal impairment, asthma, epilepsy, and migraine, or other conditions which may be aggravated by fluid retention. Progestogens can decrease glucose tolerance and diabetic patients should be carefully monitored. They should also be used with care in persons with a history of depression., It should not be given to patients with undiagnosed vaginal bleeding, nor to those with a history or current high risk of arterial disease and should generally be avoided in hepatic impairment, especially if severe. Unless progestogens are being used as part of the management of breast or genital- tract carcinoma they should not be given to patients with these conditions.,
Ref :-   Book : Martindale    Page : 2329, 2333   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Enzyme-inducing drugs such as carbamazepine, griseofulvin, phenobarbital, phenytoin, and rifampicin may enhance the clearance of levonorgestrel. These interactions are likely to reduce the efficacy of levonorgestrel-only contraceptives, and additional or alternative contraceptive measures are recommended. Aminoglutethimide markedly reduces the plasma concentrations of levonorgestrel possibly through a hepatic enzyme-inducing effect; an increase in levonorgestrel dose is likely to be required. Since levonorgestrel can influence diabetic control an adjustment in antidiabetic dosage could be required. Levonorgestrel may inhibit ciclosporin metabolism leading to increased plasma ciclosporin concentrations and a risk of toxicity. Enzyme-inducing drugs can cause combined oral contraceptives to fail by increasing their metabolism and clearance. This effect is well established for a number of antiepileptics, griseofulvin, and rifamycin antibacterials, and has also been suggested for some antivirals and for modafinil. Although less well documented, these interactions would also be expected to apply to progestogen-only contraceptives.,
Ref :-   Book : Martindale    Page : 2271,2329,2333   Edition : 37,

  ►  Mechanism of Action :   levonorgestrel are progestogens derived from nortestosterone. They are more potent inhibitors of ovulation than norethisterone and have androgenic activity.,
Ref :-   Book : Martindale    Page : 2329   Edition : 37,

Dietary Products that produce same effect as  Norgestrel/Levonorgestrel

►   Route of Elimination :   Hepatic (Metabolism), Renal, Faecal,
Ref :-   Book : Martindale    Page : 2329   Edition : 37,

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA