Medicine :   
nafcillin is a Medicine belongs to Antibacterials group whose properties about Brand can be referenced from   Book : Nelson's textbook of Pediatrics    Page : 903   Edition : 19,

  ►   Brandname : Nafcil, Unipen

  ►  Doseform : Injection with   , Capsule with 250  mg, Tablet with 500  mg, Oral solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 807   Edition : 12, Nelson's textbook of Pediatrics    Page : 903   Edition : 19, Martindale    Page : 330   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, Slow IV, IV infusion,
Reference :-   Book : Martindale    Page : 330   Edition : 37,

  ►  Indication/uses : treatment of infections due to staphylococci resistant to benzylpenicillin, Infection caused by susceptible strains of penicillinase-producing staphylococci,
Reference :-   Book : Martindale    Page : 330   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓


► nafcillin medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 Treatment of infections due to staphylococci resistant to benzylpenicillin Slow IV 0.5 1 gm Injection Nafcillin sodium may be given intravenously by slow injection over 5 to 10 minutes or by slow infusion over at least 30 to 60 minutes; usual adult doses are 0.5 to 1 g of nafcillin every 4 hours, although it is usually recommended that it be used for not more than 24 to 48 hours because of the risk of thrombophlebitis.
2 Treatment of infections due to staphylococci resistant to benzylpenicillin IM 0.5 1 gm Injection

Ref :-  Book : Martindale    Page : 330   Edition : 37,




For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 Infection caused by susceptible strains of penicillinase-producing staphylococci parenteral 25 mg/kg Injection
2 Infection caused by susceptible strains of penicillinase-producing staphylococci parenteral 25 mg/kg Injection
3 Infection caused by susceptible strains of penicillinase-producing staphylococci parenteral 25 mg/kg Injection
4 Infection caused by susceptible strains of penicillinase-producing staphylococci parenteral 25 35 mg/kg Injection
5 Infection caused by susceptible strains of penicillinase-producing staphylococci 1 Month parenteral 50 100 mg/kg Injection

Ref :- Book : Martindale    Page : 330   Edition : 37,
►  Side Effect : hypersensitivity reactions, Skin rashes, anaphylaxis, diarrhoea, nausea, sore mouth, sore tongue, black hairy tongue, Pseudomembranous colitis, haemolytic anaemia, neutropenia, prolongation of bleeding time, defective platelet function, Convulsions, encephalopathy, electrolyte disturbances, neuropathy, interstitial nephritis, Jarisch- Herxheimer reaction, fever, chills, headache, ,
Ref :-   Book : Martindale    Page : 231,330   Edition : 37,

►  Interaction : Probenecid , Chloramphenicol , , Ampicillin ,
Ref :-   Book : Martindale    Page : 232,330   Edition : 37,


►  Contraindication : hypersensitivity to penicillins, The intrathecal route should be avoided., Care is necessary if very high doses of penicillins are given, especially if renal function is poor, because of the risk of neurotoxicity. The intrathecal route should be avoided. Renal, hepatic, and haematological status should be monitored during prolonged and high-dose therapy. Because of the Jarisch-Herxheimer reaction, care is also necessary when treating patients with spirochaete infections, particularly syphilis., Thrombophlebitis may occur when nafcillin is given by intravenous injection, and tissue damage has been reported on extravasation.,
Ref :-   Book : Martindale    Page : 232,330   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Probenecid prolongs the half-life of nafcillin by competing with it for renal tubular secretion and may be used therapeutically for this purpose. Nafcillin may also interact with bacteriostatic antibacterials such as chloramphenicol and tetracyclines. The possibility of a prolonged bleeding time after oral treatment with a broad-spectrum drug like ampicillin should be borne in mind in patients receiving anticoagulants.,
Ref :-   Book : Martindale    Page : 232,330   Edition : 37,


  ►  Mechanism of Action :   It is active against penicillinase-producing and non-penicillinase-producing staphylococci. Its activity against streptococci such as Streptococcus pneumoniae and Str. pyogenes is less than that of benzylpenicillin, but sufficient to be useful when these organisms are present with penicillin-resistant staphylococci.,
Ref :-   Book : Martindale    Page : 301,330   Edition : 37,
 ►   

Dietary Products that produce same effect as  nafcillin






►   Route of Elimination :   Hepatic (Metabolism), Biliary, Renal,
Ref :-   Book : Martindale    Page : 330   Edition : 37,


►    Plasma Half-life :   Min value :-   0.5 hours,    Max value :-   1.5 hours,
Ref :-   Book : Martindale    Page : 330   Edition : 37,


►    Peak Plasma Concentration :   Min value :-   0.5 hours,    Max value :-   1 hours,
Ref :-   Book : Martindale    Page : 330   Edition : 37,