Medicine :   
nelfinavir is a Medicine belongs to Antiviral group whose properties about Brand can be referenced from   Book : Martindale    Page : 992   Edition : 37,

  ►   Brandname : Viracept, Nelvir

  ►  Doseform : Tablet with 250  mg, Tablet with 625  mg, Powder with 50  mg/gm,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 992   Edition : 37,

  ►  Indication/uses : HIV infection and AIDS,
Reference :-   Book : Martindale    Page : 992   Edition : 37,
Dosing of Medicine differ in Adult & Pediatrics ↓

► nelfinavir medicine for Adults :

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage   Frequency   Additional Info
1 HIV infection and AIDS Oral 1.25 gm Tablet o.d. Given with food
2 HIV infection and AIDS Oral 750 mg Tablet t.i.d. Given with food.

Ref :-  Book : Martindale    Page : 992   Edition : 37,

For Pediatric :
S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage   Additional Info  
1 HIV infection and AIDS 3 Year Oral 50 55 mg/kg
2 HIV infection and AIDS 2 Year Oral 45 55 mg/kg

Ref :- Book : Martindale    Page : 992   Edition : 37,
►  Side Effect : diarrhoea, Flatulence, nausea, rash, raised liver enzymes, decreases in white blood cell counts, Immune reconstitution syndrome, severe immune deficiency, lipodystrophy, central obesity, Dorsocervical fat enlargement (buffalo hump), peripheral wasting, facial wasting, breast enlargement, cushingoid appearance, hypertriglyceridaemia, insulin resistance, Hyperglycaemia, Hyperlactataemia, Elevated creatine phosphokinase, myalgia, myositis, ,
Ref :-   Book : Martindale    Page : 991   Edition : 37,

►  Interaction : , Alfuzosin , , Amiodarone , Quinidine , , Astemizole, Terfenadine, , dihydroergotamine, Ergometrine , Ergotamine, Methylergometrine, , Cisapride , , Pimozide , Selegiline , , Midazolam , , Triazolam , Simvastatin , Lovastatin , Sildenafil , Omeprazole , Rifampicin ,
Ref :-   Book : Martindale    Page : 992   Edition : 37,

►  Contraindication : Nelfinavir should be used with caution, and liver enzyme values monitored, in patients with moderate liver disease; in the USA, the use of nelfinavir in patients with moderate or severe liver disease is not advised., Patients co-infected with chronic hepatitis B or C and treated with combination antiretroviral therapy are at increased risk for severe and potentially fatal hepatic adverse events. Caution is advised in treating patients with haemophilia A and B as reports of spontaneous bleeding have been associated with the use of HIV-protease inhibitors.,
Ref :-   Book : Martindale    Page : 992   Edition : 37,
  ►    Mechanism of Drug Drug Interaction :  Nelfinavir is reported to be metabolised in part by cytochrome P450 isoenzymes CYP3A4 and CYP2C19. Drugs that induce these isoenzymes may reduce the plasma concentration of nelfinavir. Conversely, when nelfinavir is given with drugs that inhibit CYP3A4 plasma concentrations, nelfinavir concentrations may be increased. It may also alter the pharmacokinetics of drugs metabolised by this isoenzyme system and possibly cause serious adverse effects. Nelfinavir is contra-indicated with drugs that are highly dependent on CYP3A4 for clearance and for which elevated plasma concentrations are associated with serious or life-threatening events. These drugs include the alpha1-adrenoreceptor antagonist alfuzosin, antiarrhythmics (amiodarone and quinidine), antihistamines (astemizole and terfenadine), ergot derivatives (dihydroergotamine, ergometrine, ergotamine, and methylergometrine), gastrointestinal motility agents (cisapride), antipsychotics (pimozide), sedatives and hypnotics (midazolam and triazolam), and statins (simvastatin and lovastatin). Owing to the potential for increased serum concentrations of sildenafil, nelfinavir should be avoided with sildenafil when given at the doses needed for the treatment of pulmonary hypertension. Similarly, nelfinavir may increase serum concentrations of inhaled salmeterol and the combination is not recommended. Omeprazole, rifampicin, and St John’s wort decrease the concentration of nelfinavir; use with the antiretroviral is not recommended due to the possible loss of its activity and development of resistance. ,
Ref :-   Book : Martindale    Page : 992   Edition : 37,

  ►  Mechanism of Action :   Nelfinavir is a selective, reversible inhibitor of HIV-1 protease. It interferes with the formation of essential viral proteins making them incapable of infecting other cells. Viral resistance develops rapidly when HIV-pro-tease inhibitors are given alone and therefore they are used with other antiretrovirals. Mechanisms of resistance to nelfinavir may differ sufficiently from those to other HIV-protease inhibitors to reduce the occurrence of cross-resistance between nelfinavir and other HIVprotease inhibitors. Cross-resistance between nelfinavir and NNRTIs is unlikely because they target different enzymes.,
Ref :-   Book : Martindale    Page : 992   Edition : 37,

Dietary Products that produce same effect as  nelfinavir

►   Route of Elimination :   Renal, Faecal,
Ref :-   Book : Martindale    Page : 992   Edition : 37,

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
Ref :-   Book : Martindale    Page : 992   Edition : 37,